KUHS MBBS Pharmacology Previous Question Paper - March 2025 (212001 2019 Scheme)

212001Kerala University of Health Sciences · Pharmacology · 2025 · March · 2019 Scheme

Questions (18)

1.Single Response Type
The potent inhibitor of bacterial cell wall synthesis used for Neisseria gonorrhoeae infections is: a) Ceftriaxone c) Erythromycin b) Clindamycin d) Trimethoprim-sulfamethoxazole
Which anti-diarrhoeal drug acts by inhibiting intestinal motility via opioid receptors a) Loperamide b) Bismuth subsalicylate c) Dicyclomine d) Mesalamine
The anticancer drug which acts by inhibiting Topoisomerase II, thereby causing DNA strand breaks is: a) Methotrexate b) Doxorubicin c) Vinblastine d) 5-Fluorouracil
The mechanism of action of the drug terbinafine is: a) Inhibition of fungal cell wall synthesis b) Disruption of fungal cell membrane integrity c) Inhibition of squalene epoxidase in the ergosterol synthesis pathway d) Inhibition of fungal DNA synthesis
Which of the following is the most common adverse effect of long-term use of oral contraceptives a) Cataract b) Thromboembolism c) Hypothyroidism d) Hyperkalemia
5 Marks
2.Multiple Response Type. Read the statements and mark the answers appropriately
The antibiotics known to target bacterial protein synthesis are: 1) Erythromycin 2) Ciprofloxacin 3) Tetracycline 4) Vancomycin a) 1 & 4 are correct b) 1 & 2 are correct c) 1 & 3 are correct d) 2 & 4 are correct
Which drugs are used as part of post-exposure prophylaxis (PEP) in HIV exposure 1) Emtricitabine 2) Tenofovir 3) Enfuvirtide 4) Zidovudine a) 1 & 4 are correct b) 1 & 2 are correct c) 1 & 3 are correct d) 2 & 4 are correct
The drugs widely preferred to treat irritable bowel syndrome (IBS) 1) Sulfasalazine 2) Dicyclomine 3) Metronidazole 4) Ondansetron a) 1 & 4 are correct b) 1 & 2 are correct c) 1 & 3 are correct d) 2 & 4 are correct
The drug safe in pregnancy 1) Amoxicillin 2) Ciprofloxacin 3) Cefixime 4) Tetracycline a) 1 & 2 are correct b) 1 & 3 are correct c) 1 & 4 are correct d) 2 & 4 are correct
The anticancer agents causing renal toxicity as adverse effect are: 1) Cisplatin 2) Methotrexate 3) Cyclophosphamide 4) Trastuzumab a) 2 & 4 are correct b) 1 & 2 are correct c) 1 & 3 are correct d) 1 & 4 are correct
5 Marks
3.Patient: Mr. John Taylor, a 45-year-old man presents with the chief complaint: Severe heartburn and regurgitation of food after meals, especially at night. Medical History: Overweight (BMI: 29), Occasional alcohol use. No known drug allergies. Presenting Symptoms: Heartburn and acid regurgitation after meals for the past 3 months. Symptoms are worse when lying down, particularly at night. Difficulty swallowing at times. Has been self-medicating with over-the-counter antacids but reports no significant relief. Physical Examination: Normal vital signs, No signs of systemic illness, abdominal tenderness or masses and not anaemic. Diagnosis: Gastroesophageal reflux disease (GERD)
Mr. Taylor’s symptoms are poorly controlled with over-the-counter antacids. Which of the following is the most appropriate next step in his treatment a) Increase the dose of antacids c) Prescribe a prokinetic agent b) Start a Proton Pump Inhibitor (PPI) d) Recommend a high-fiber diet
The known side effect of long-term use of proton pump inhibitors (PPIs) is a) Hyperglycemia b) Hypercalcemia c) Vitamin B12 deficiency d) Relapse of GERD
Which of the following classes of drugs is most commonly used as the first-line pharmacologic treatment for GERD a) Proton pump inhibitors (PPIs) c) Antacids b) H2-receptor antagonists d) Prokinetic agents
The drug preferred as an adjunctive therapy in GERD by accelerating gastric emptying is a) Metoclopramide b) Lansoprazole c) Ranitidine d) Sucralfate
The primary mechanism of action of H2-receptor antagonists in the treatment of GERD is a) Increase gastric acid secretion c) Improve gastric motility b) Decrease gastric acid secretion d) Neutralize gastric acid
5 Marks
4.Two statements – Assertion (A) and Reason (R). Answer these questions by selecting the appropriate options given below
Assertion (A): Sulphonamide’s can cause kernicterus in newborns. Reason (R): Drugs with low plasma protein binding can cause hemolysis. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
Assertion (A): Propranolol is often used to manage symptoms of hyperthyroidism. Reason (R): Propranolol is a non-selective beta-blocker that reduces the symptoms of hyperthyroidism by blocking the effects of excessive thyroid hormones on the heart. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
Assertion (A): Vancomycin is used primarily to treat infections caused by Methicillin-resistant Staphylococcus aureus (MRSA). Reason (R): Vancomycin inhibits the formation of bacterial cell walls by binding to D-alanylD-alanine, a component of the peptidoglycan precursor. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
Assertion (A): Azathioprine dose is decreased with Allopurinol. Reason (R): Azathioprine and allopurinol cause bone marrow suppression. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
Assertion (A): Bedaquiline is used along with clofazimine in XDR TB. Reason (R): Two drugs acting on same target can antagonize each other. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
5 Marks
5.Classify antifungal drugs. Explain the mechanism of action, uses, and adverse effects of Amphotericin B. Add a note on the various liposomal formulations of Amphotericin B
10 Marks
6.A 30 year old female with systemic lupus erythamatosis was given prednisolone 40 mg/day a) What are the precautions to be taken in this patient. Why. b) Enumerate four clinical uses of corticosteroids, with its rationale for use c) Enumerate four serious adverse effects of prolonged steroid use
10 Marks
7.Classify uterine stimulants and relaxants with suitable examples. Explain the rationale for the use of oxytocin in prevention of postpartum haemorrhage (PPH).
6 Marks
8.Write in detail on the mechanism of action, uses, and adverse effects of aminoglycoside antibiotics.
6 Marks
9.Enumerate Antiemetics. Add a brief note on mechanism of action, uses and adverse effects of the most effective group
6 Marks
10.Enumerate SERMs. Write in detail about any one member.
6 Marks
11.Mechanism of action, therapeutic uses and adverse effects of vinca alkaloids.
6 Marks
12.A 60-year-old lady presents with back pain and in the legs. She also complains of a recent fracture in the right wrist joint. After investigation, the physician made a diagnosis of Osteoporosis. She was prescribed Alendronate. Explain the mechanism of action and adverse effects of Alendronate.
6 Marks
13.Enumerate SERMs. Write in detail about any one member
4 Marks
14.What is the pharmacological basis for the use of pyridoxine along with isoniazid.
4 Marks
15.Mechanism of action, uses and adverse effects of Radio active iodine.
4 Marks
16.Contra indications and drug interactions of oral contraceptive pills.
4 Marks
17.Enumerate insulin analogues and tabulate their pharmacokinetic characteristics.
4 Marks
18.Discuss the role of empathy in patient care.
4 Marks

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