Kaloji Narayana Rao University of Health Sciences Bachelor of Medicine and Bachelor of SurgeryPathology Previous Year Question Papers

Defect in sickle cell disease is a) Glutamate residue instead of a valine residue at the 6th amino acid position in (3-globin b) Valine residue instead of a glutamate residue at the 6th amino acid position in 13-globin c) Glutamate residue instead of a valine residue at the 6th amino acid position in a -globin d) Valine residue instead of a glutamate residue at the 6th amino acid position in a-globin

Defective platelet aggregation is seen in a) Bernard-Soulier syndrome b) Glanzman’s syndrome c) Haemophilia d) Vitamin K deficiency

All the following ovarian tumors arise from surface epithelium except: a) Teratoma b) Serous cystadenoma c) Mucinous cystadenocarcinoma d) Brenner tumour

Nodular glomerulosclerosis is characteristic feature of: a) Amyloidosis b) SLE c) Membranous glomerulonephritis d) Diabetes Mellitus

Irreversibility following cell injury is consistently characterized by a) loss of mitochondrial function b) fatty change c) Vacuolar degeneration d) hypertrophy of endoplasmic reticulum

The following hepatitis virus is a DNA virus: a) Hepatitis A b) Hepatitis B c) Hepatitis C d) Hepatitis E

Hodgkin lymphoma with frequent mononuclear cells and classical Reed Sternberg a) Nodular sclerosis b) Lymphocyte depletion c) Mixed cellularity d) Lymphocyte predominance

An young man met with a road accident and had left femoral fracture after which his leg was immobilized in a plaster cast for 6 weeks following which the diameter of the left calf was decreased in size. This change in size is most likely to result from which of the following alterations in his calf muscles? a) Hyperplasia b) Atrophy c) Dystrophy d) Hyalinosis

Sunray appearance in osteosarcoma is due to? a) Periosteal reaction b) Osteonecrosis c) Formation of osteoid along vessels d) Calcification

What is FALSE about Phaeochromocytoma? a) A tumour of adrenal cortex b) Tumour secretes epinephrine and norepinephrine c) Tumour cells are chromaffin positive d) Clinically associated with labile hypertension

Not a cardinal sign of inflammation is a) Palor b) Calor c) Dolor d) Loss of function

The most common soft tissue tumour in adults is a) Synovial sarcoma b) Lipoma c) Neurofibroma d) Fibroma

Idiopathic thrombocytopenic purpura is characterized by: a) Decreased platelet survival b) Decreased production of platelets c) Hypersplenism d) Dilutional thrombocytopenia

In case of tissue subjected to hypoxic damage the cells in this tissue begin to swell with chromatin clumping in cell nuclei, ATPases are activated, and ATP production decreases. Which of the following ions accumulating in mitochondria and the cytosol contributes most to these findings and to eventual cell death? a) Ca2+ b) Cl- c) HCO3- d) K+

Medial calcific sclerosis is a type of a) Metastatic calcification b) Dystrophic calcification c) Both metastatic and dystrophic calcification d) Neither metastatic nor dystrophic calcification

Commonest sarcoma in children is- a) Rhabdomyosarcoma b) Lipoma c) Angiosarcoma d) Fibrosarcoma

Oedema resulting from renal dysfunction often manifests first in a) Legs b) Sacral region c) Peri-orbital region d) Lungs

Organ not involved in MEN-1 syndrome is a) Parathyroid b) Pancreas c) Thyroid d) Pituitary

Bombay phenotype are the individuals who: a) Lack H genes and therefore H substance b) Possess A, B antigens c) Secrete excessive amount of H substance d) Lack C, D and E antigens

A child with a history of recurrent infections with pyogenic bacteria had an area of soft tissue necrosis and the microscopic examination of the biopsy obtained from this tissue showed microbial organisms, but very few neutrophils. The analysis of the case showed neutrophil functional defect involving rolling. The most probable cause of increased susceptibility to infection is a defect involving which of the following molecules? a) Selectins b) Complement C3b c) Integrins d) Leukotriene B4

Cell of origin of meningioma is from: a) Dura mater b) Arachnoid cap cell layer c) Pia mater d) Choroid plexus

Pulseless disease is an alternative name for a) Temporal arteritis b) Kawasaki's disease c) Buerger's disease d) Takayasu arteritis

Nutmeg liver is the description of morphology occurring in which of the following conditions a) Hyperaemia of liver b) Chronic venous congestion of liver c) Cirrhosis of liver d) Inflammation of liver

MacCallum's patch appears in the region of: a) Endocardial surface in the posterior wall of left atrium b) Pericardial surface in the posterior wall of left ventricle c) Pericardial surface in the posterior wall of left atrium d) Endocardial surface in the posterior wall of left ventricle

Cyclin dependent Kinases are all except a) P57 b) P21 c) P53 d) P27

Diabetic foot is an example of: a) Dry gangrene b) Wet gangrene c) Gas gangrene d) Necrotizing inflammation

A 55 year-old man presented with sudden onset of bleeding on defecation and had history of changes in bowel habits, cramping and left lower quadrant discomfort. He was found to be having adenocarcinoma of colon. Which part is affected in such a case? a) Rectum b) Descending colon c) Caecum and ileo caecal valve d) Ascending colon

Locally invasive skin tumor called Rodent ulcer is a) Squamous cell carcinoma b) Basal cell carcinoma c) Sebaceous carcinoma d) Cylindroma

CREST syndrome is associated with a) SLE b) Systemic sclerosis c) Sjogren syndrome d) Rheumatoid arthritis

A 60-year-old man, who is a chain-smoker had cough and weight loss since 3 months. Physical examination shows clubbing of the fingers. A chest radiograph shows no hilar adenopathy, but there is cavitation within a 3-cm lesion near the right hilum. Laboratory tests show mild anaemia and hypercalcemia. Bronchoscopy shows a lesion almost occluding the right main bronchus. What is the most probable neoplasm? a) Adenocarcinoma in situ b) Squamous cell carcinoma c) Large cell anaplastic carcinoma d) Metastatic renal cell carcinoma

Not a stain for Amyloid is a) Congo red b) Methyl violet c) Triphenyl tetrazolium chloride d) Thioflavin T

Enzyme which prevents cell ageing a) Catalase b) Superoxide dismutase c) Metalloproteinase d) Telomerase

A 34-year-old woman sustained trauma to her right breast. Initially, there was a 3-cm contusion beneath the skin that resolved within 3 weeks, but she then felt a firm, painless lump that persisted below the site of the bruise 1 month later. What is the most likely diagnosis for this lump? a) Abscess b) Fat necrosis c) Fibroadenoma d) Sclerosing adenosis

Classic perivascular structures seen in testicular yolk sac tumours are known as: a) Schiller -Duval bodies b) Call—Exner bodies c) Michaelis-Guttmann bodies d) Russel bodies

Identify the misnomer a) chondroma b) Papilloma c) Seminoma d) Lymphangioma

Not a Sex cord tumour of ovary is a) Granulosa cell tumour b) Dysgerminoma c) Thecoma d) Leydig cell tumour

Not a cause of oedema is a) Increased hydrostatic pressure b) Increased plasma oncotic pressure c) Lymphatic obstruction d) Sodium retention

Amyloidosis results from abnormal folding of proteins, which are insoluble, aggregate, and deposit as: a) Fibrils in extracellular tissues b) Intracellular deposits c) Intranuclear inclusions d) In the meninges

A 76-year-old man has a slowly enlarging nodule on his right eyelid for 4 years. On physical examination, there is a 0.3-cm pearly nodule on the upper eyelid. The lesion is excised, with wider margins removed taking care to preserve the eyelid. The microscopic appearance of the lesion shows dark tumor cells arranged in nests having peripheral palisading. What is the most likely diagnosis? a) Actinic keratosis b) Basal cell carcinoma c) Dermatofibroma d) Malignant melanoma

The most frequent association of squamous cell carcinoma penis is with a) HPV type 6 b) HPV type 11 c) HPV type 44 d) HPV type 16

Rarest site for tumor metastasis is a) Bone b) Lung c) Liver d) Skeletal muscle

Classify Tumours of Large Intestine. Discuss the etiopathogenesis and morphology of Colonic Cancer.

Define Apoptosis. Describe morphological features and mechanism of Apoptosis.

Define Necrosis. Discuss in detail about different types of Necrosis with suitable examples.

A 8 year old boy was admitted with history of puffiness of face and passing of red coloured urine, following upper respiratory tract infection 2 weeks earlier. Urine examination showed moderated proteinuria and haematuria. a. What is your probable diagnosis? b. Describe the etiopathogenesis of that condition. c. Give the morphology of the organ affected. d. List the investigations that you would do to confirm diagnosis.

Classify Tumours of Bone. Describe gross and microscopy of Osteosarcoma.

Define Amyloidosis. Explain the gross and microscopic features of the organs involved in secondary Amyloidosis with its staining reactions.

Define and classify Pneumonia. Discuss the pathology and complications of Lobar Pneumonia.

Define and Classify of Leukaemia. Discuss the Chromosomal abnormality and lab findings in Chronic Myeloid Leukaemia.

A 2-year-old child was brought Paediatric outpatient with history of failure to thrive. O/E child is Anaemic with mongoloid face, i.e. with Malar Eminence, Frontal bossing, X-ray skull shows hair on end appearance, moderate splenomegaly and hepatomegaly. What is your provisional diagnosis? Discuss about pathogenesis and lab diagnosis of this condition.

Classify Cirrhosis. Describe the pathogenesis and pathology of Alcoholic Cirrhosis.

Describe the pathogenesis, gross, microscopy and complications of Gastric Ulcer.

Classify Haemolytic Anaemia. Discuss the laboratory diagnosis of Haemolytic Anaemia.

Bronchiectasis.

Discuss about pathological Calcification.

Fat Embolism.

Discuss the pathology of Dysgerminoma.

Cirrhosis of Liver

Chemotaxis.

Complications of Myocardial Infarction.

Describe Gaucher’s Disease.

Special stains used to demonstrate Amyloid.

Describe the pathogenesis of Barett’s Oesophagus.

Kidney changes in Diabetes Mellitus.

Etiopathogenesis of Thrombus.

Nephrotic Syndrome.

Von Willebrand’s Disease.

Classify Hodgkin’s disease. Add a note on Nodular Sclerosis.

Silicosis.

Gall Stones.

Neimann Pick disease.

Acute pancreatitis.

Transplant rejection.

WHO classification of AML.

Cryptorchidism.

Hashimoto’s Thyroiditis.

Leukemoid reaction.

Renal changes in Diabetes.

Factors affecting Wound Healing.

Down’s syndrome.

Discuss gross and microscopy of Phyllodes Tumour.

Basal cell carcinoma.

Rickets.

Choriocarcinoma.

Pathology of Vitamin D deficiency.

Ochronosis.

Discuss the pathology of Pheochromocytoma.

Rheumatic Heart Disease.

Mycetoma.

Write the morphology of Osteosarcoma.

Aplastic Anaemia.

Complications of Wound Healing.

Osteoclastoma.

Emphysema.

Paraneoplastic Syndrome

Mallory Weiss Syndrome.

Three types of Necrosis with examples.

Differences between Transudate and Exudate.

Enumerate risk factors of Carcinoma Cervix.

Enumerate the causes of Cryptorchidism.

Caisson’s Disease.

MacCallum Plaques.

CSF findings in Pyogenic Meningitis.

Bence Jones Protein.

Classify Thyroid tumour.

Paget’s disease of Nipple.

Hyper segmented Neutrophil.

Pyogenic Osteomyelitis.

Three Opportunistic infections in HIV infection.

CSF in Pyogenic Meningitis.

Types of Emphysema.

Enumerate any three Testicular Tumours.

Barr body.

Astrocytoma.

Morphology of Megaloblast.

Microscopy of Rhinosporidiosis.

Aschoff’s Body.

Hyperparathyroidism.

Negri bodies.

Define and enumerate the causes of Aneurysms.

Enumerate anticoagulants in Haematology.

Granuloma.

Uses of Buffy Coat.

Schwannoma.

Indications of Semen Analysis.

Bone marrow picture in B12 deficiency.

Morphology of Warthin’s Tumour.

Teratoma.

Virchow’s triad.