Dr. NTR University of Health Sciences Bachelor of Medicine and Bachelor of Surgery 2nd Year Pharmacology Previous Year Question Papers

1.

Classify beta-blockers, Write a note on cardiovascular and on cardiovascular indications of beta-blockers. List the significant adverse effects and drug interactions of beta- blockers. Discuss the management of hypertensive emergency

15 Marks

2.

List the different groups of oral anti-diabetic agents with examples. Explain in detail the mechanism of action and adverse effects of any one group. Enumerate the insulin preparations and outline the adverse effects of insulin with its management. Add a note on diabetic ketoacidosis

15 Marks

3.

Discuss the pathophysiology of Parkinson's disease and different group of drugs used for its treatment Discuss the rationale for levodopa carbidopa combination. Write briefly about different strategies to prevent wearing off phenomenon during its treatment. Add a note on drug induced parkinsonism and its treatment

15 Marks

4.

Enumerate the drugs used in the treatment of pulmonary tuberculosis. Explain the mechanism of action and adverse effects of one of the first line antitubercular drug. Discuss the treatment of multi drug resistant tuberculosis

15 Marks

5.

Discuss the clinical significance of plasma protein binding

5 Marks

6.

Write the composition of oral rehydration salt solution and its role in diarrhea

5 Marks

7.

Write about the parenteral routes of drug administration

5 Marks

8.

Compare and contrast heparin and warfarin

5 Marks

9.

Discuss briefly about the Pharmacovigilance program of India

5 Marks

10.

Describe the therapeutic uses of corticosteroids

5 Marks

11.

A farmer presented to the emergency department with signs and symptoms suggestive of organophosphorus poisoning. How will you manage this case. Give justification for the drugs to be used

5 Marks

12.

Write about the management of psoriasis

5 Marks

13.

Describe the uses and adverse effects of Thiazide diuretics

5 Marks

14.

Enumerate the iron preparations and add a note on the indications of parenteral iron therapy

5 Marks

15.

Add a not on different dose of aspirin and its therapeutic uses

5 Marks

16.

A 36-year-old female patient had history of acid peptic disease and endoscopic biopsy was suggestive of helicobacter pylori infection. Describe the pharmacological management of this case

5 Marks

17.

Discuss the role of steroids in asthma

5 Marks

18.

A 25-year-old male developed and infection due to Methicillin Resistant Staphylococcus Aureus (MRSA). Describe in brief the drugs available to treat such infection

5 Marks

19.

Write the role of statins as cholesterol lowering agent

5 Marks

20.

Discuss the treatment of uncomplicated malaria

5 Marks

21.

Enumerate the obstetrics and gynecological uses of prostaglandin analogues

5 Marks

22.

Write about the toxicity amelioration of anticancer agents

5 Marks

23.

After injecting succinylcholine I.V, to have muscle relaxation during a surgical procedure, a patient developed prolonged apnea. What could be the probable cause. What is the management for the above condition

5 Marks

24.

Explain the management of paracetamol poisoning

5 Marks

25.

All of the following antimalarial drugs are 4-aminoquinoline derivatives EXCEPT a. Chloroquine b. Piperaquine c. Primaquine d. Amodiaquine

1 Mark

26.

Which of the following combination is the current gold standard treatment for HIV associated cryptococcal meningitis a. Flucytosine + Amphotericin B b. Fluconazole + Amphotericin B c. Voriconazole + Flucytosine d. Fluconazole + Caspofungin

1 Mark

27.

Which of the following antimicrotubular agent is used in the treatment of prostrate cancer a. Paclitaxel b. Docetaxel c. Estramustine d. Vincristine

1 Mark

28.

Which of the following amphotericin formulations is least like to cause infusion-related reactions a. Amphotericin B deoxycholate b. Amphotericin B colloidal dispersion c. Amphotericin B lipid complex d. Liposomal amphotericin B

1 Mark

29.

Cephalosporin used in MRSA infection a. Ceftaroline b. Ceftalozone c. Ceftazidime d. Cefotaxime

1 Mark

30.

The thiazolidinedione withdrawn from the market due to hepatoxicity is a. Pioglitazone b. Rosiglitazone c. Troglitazone d. Lobeglitazone

1 Mark

31.

Synthetic levothyroxine is stored in dark bottles to a. minimize spontaneous deiodination b. Avoid changes in brand bioavailability c. Improve efficacy d. Reduce product antigenicity

1 Mark

32.

Drugs inhibiting 5 - deiodinase and decreasing T3 level include ail of the following EXCEPT a. Lithium b. Amiodarone c. Beta-blockers d. Propylthiouracil

1 Mark

33.

The Selective Estrogen Receptor Modular (SERM) that is approved treatment of menopausal symptoms and for Prophylaxis of postmenopausal osteoporosis in combination with conjugated estrogen is a. Lasofoxifene b. Raloxifene c. Bazedoxifene d. Toremifene

1 Mark

34.

Antacid combinations for well sustained effect are most likely composed of a. Calcium and magnesium salts b. Calcium and aluminum salts c. Aluminum and magnesium salts d. Sodium bicarbonate and Magnesium salts

1 Mark

35.

QT interval prolongation occurs as an adverse effect of a. Domperidone b. Metoclopramide c. Cisapride d. Omeprazole

1 Mark

36.

Atropine is added to commercial preparations containing diphenoxylate to a. Potentiate anti-spasmodic effect b. To reduce excretion of salt and water c. To prevent overdosage and discourage opioid dependence d. To prolong its duration of action

1 Mark

37.

Which of the following metabolic adverse effect is caused by cyclosporine a. Hypokalemia b. Hyperkalemia c. Hypercalcemia d. Hypocalcemia

1 Mark

38.

Which of the following has immunostimulant action a. Prednisolone b. Levamisole c. Cyclosporine d. Thalidomide

1 Mark

39.

An Ectoparasiticide which induce CYP isoenzymes and produce cardiac arrhythmias is a. Permethrin b. Sulfur c. Crotamiton d. Lindane

1 Mark

40.

Which of the following type of Human papillomavirus (HPV) vaccine is used for prevention of cervical cancers in female a. Bivalent vaccine (HPV2) b. Quadrivalent vaccine (HPV4) c. Pentavalent vaccine (HPV5) d. 9 valent vaccine (HPV9)

1 Mark

41.

The following anti-epileptic can also be used in the management of obesity a. Valproate b. Lamotrigine c. Lacosamide d. Topiramate

1 Mark

42.

Which of the following is given to treat chemotherapy induced thrombocytopenia a. Epoetin alfa b. Plerixafor c. Filgrastim d. Oprelvekin

1 Mark

43.

Which of the following GP IIB/IIIa antagonist is a peptide a. Abciximab b. Tirofiban c. Eptifibatide d. Ticagrelor

1 Mark

44.

Anticoagulant that can be given in Heparin induced Thrombocytopenia (HIT) is a. Daiteparin b. warfarin c. Fondaparinux d. Enoxaparin

1 Mark

Dr. NTR University of Health Sciences Bachelor of Medicine and Bachelor of SurgeryPharmacology Previous Year Question Papers