KUHS MBBS Microbiology Previous Question Paper - December 2024 (216001 2019 Scheme)

216001Kerala University of Health Sciences · Microbiology · 2024 · December · 2019 Scheme

Questions (15)

1.A 4 year old boy was brought to the emergency with a history of altered sensorium, inability to eat and one episode of seizure in the last 2 days. The child used to play with street dogs. i. What is the likely clinical diagnosis a) Guillain barre syndrome c) Rabies b) ECHO virus encephalitis d) Herpes Simplex encephalitis ii. An antemortem diagnostic method is a) Negri bodies in brain by Immunohistochemistry c) Antibody detection in saliva b) Antigen in corneal smear by immunofluorescence d) RNA in brain by RTPCR iii. Vaccine to prevent rabies in humans is a) Sheep brain vaccine b) Neural vaccine c) Human diploid cell vaccine d) Jeryl Lynn vaccine iv. Rabies virus can be transmitted to humans by all of the following routes EXCEPT a) Bite by infected bats c) Cornea transplantation b) Inhalation of virus containing aerosols d) Consumption of raw milk of infected animals v. The protein which acts as virulence factor is the a) Nucleoprotein b) Glycoprotein G c) Matrix protein d) Hemagglutinin Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the answers appropriately. vi. Cholera 1) Has potential to cause pandemics 2) Hanging drop test of stool sample helps in rapid diagnosis 3) Causes dysentery in children 4) Can present as hypovolemic shock in severe cases leading to death a) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct vii. Bile-stained eggs are seen in infection with 1) Ascaris 2) Hookworm 3) Trichuris 4) Taenia a) 1, 2, 3 are correct b) 1, 2, 4 are correct c) 1, 3, 4 are correct d) 2, 3, 4 are correct viii. Hand foot and mouth disease is NOT caused by 1) Cytomegalovirus 2) Coxsackie virus 3) Calicivirus 4) ECHO virus a) 1, 2, 3 are correct b) 2, 3, 4 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct ix. This is NOT a mode of transmission of Schistosoma hematobium 1) Bite of Tsetse fly 2) Consumption of vegetables contaminated with metacercaria 3) Penetration of cercaria through the skin 4) Blood transfusion a) 2, 3, 4 are correct b) 1, 2, 3 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct x. A 28 year old male, following consumption of canned food, came with complaints of difficulty in swallowing, blurred vision, which soon progressed to respiratory paralysis. This bacteria is NOT the likely etiology. 1) Enterotoxigenic Escherichia coli 2) Clostridium botulinum 3) Campylobacter jejuni 4) Yersinia enterocolitica a) 1, 2, 4 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 3 are correct Question numbers (xi) – (xv) are single response types xi. Which of the following parasites causes keratitis. a) Acanthamoeba b) Naegleria c) Balamuthia d) Sappinia xii. Meningitis caused by the following agents can be prevented by vaccination EXCEPT a) Neisseria meningitidis c) Hemophilus influenzae b) Streptococcus pneumoniae d) Listeria monocytogenes xiii. Swimming pool granuloma is caused by Mycobacterium a) marinum b) kansasii c) ulcerans d) abscessus xiv. River blindness is caused by a) Brugia malayi b) Oncocerca volvulus c) Loa loa d) Mansonella species xv. Diphtheria vaccine is a a) Subunit vaccine b) Toxoid vaccine c) Whole cell vaccine d) Recombinant vaccine Question numbers (xvi) – (xx) consists of two Statements-Assertion (A) and Reason (R). Answer these questions by selecting the appropriate options given below. xvi. A: Whooping cough is caused by Bordetella pertussis. R: Whooping cough is mainly seen in adults. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true xvii. A: Specific antivirals are available to treat Japanese Encephalitis. R: Japanese Encephalitis is the most common cause of vaccine preventable encephalitis in Asia. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true xviii. A: Cryptococcus neoformans cannot be cultured. R: Rapid diagnosis of Cryptococcal meningitis can be done on CSF sample by India Ink preparation. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true xix. A: Hepatitis B virus is preventable by vaccination. R: Hepatitis B can be transmitted parenterally. a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true xx. A: Plasmodium falciparum is the species of Plasmodium producing most serious complications. R: Malaria is caused by bite of female Anopheles mosquito a) Both A and R are true and R is the correct explanation of A c) A is true but R is false b) Both A and R are true and R is not the correct explanation of A d) A is false but R is true
20 Marks
2.A 70 year old man was brought to the emergency department with fever, cough, and dyspnoea. Physical examination revealed a dull note on percussion. X-ray chest revealed a patch on the right lung area. The gram stain of sputum sample revealed numerous pus cells and Gram positive lanceolate shaped diplococci. a) What is the clinical diagnosis and what is the probable etiological agent. b) What culture media is used to enable the growth of the organism suspected and how will you confirm the identity of the organism. c) Discuss the virulence factors and pathogenesis of this etiological agent. d) What are the vaccines available for this etiological agent. Discuss.
10 Marks
3.A 30 year old female was brought to the hospital with complaints of loss of weight and appetite of 3 months duration. On examination, she was jaundiced and hepatomegaly present. she gave a history of blood transfusion in the past. Lab investigation showed she was HBsAg positive. a) What is the most probable clinical diagnosis. b) What are the different modes of transmission of this agent. c) Discuss the laboratory diagnosis of this infection. d) Add a note on the immunoprophylaxis
10 Marks
4.Hydatid disease.
6 Marks
5.Define pandemic. Name any four pandemics. Describe in detail strategies taken for their control.
6 Marks
6.List FOUR clinically important anaerobes. List samples to be collected. Describe the sample collection process.
6 Marks
7.Primary Amoebic meningoencephalitis – discuss etiology, pathogenesis and laboratory diagnosis.
6 Marks
8.Mode of transmission, clinical presentation and laboratory diagnosis of Nipah virus infection
6 Marks
9.Shigellosis.
6 Marks
10.Antibiotic associated diarrhea.
4 Marks
11.List, in tabular form, the CSF parameters, in normal CSF and in pyogenic, viral and tubercular meningitis.
4 Marks
12.How will you instruct a patient with suspected lower respiratory tract infection to collect a sputum sample.
4 Marks
13.How is Toxoplasma gondii transmitted. Add a note on the laboratory diagnosis of congenital Toxoplasma infection.
4 Marks
14.Modes of transmission and laboratory diagnosis of Monkey pox (M Pox)
4 Marks
15.List FOUR oncogenic viruses.
4 Marks

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