KUHS MBBS Pathology Previous Question Paper - February 2022 (213001 2019 Scheme)

213001Kerala University of Health Sciences · Pathology · 2022 · February · 2019 Scheme

Questions (22)

1.A 60-year-old man presents to the medical OPD with complaints of easy fatiguability, bone pain and decreased urination. On examination, he has pallor. Systemic examination is normal. Hemogram shows Hb- 8gm%, TLC of 6500/mm3 and platelet count of 1,60,000/mm3. The differential leucocyte count is normal. Peripheral smear shows increase in Rouleaux formation. ESR is 110mm/first hour. Serum Creatinine of 3.8gm%. A bone marrow examination was ordered the next day. • What is the most likely possibility in such a situation • What are the findings expected in a bone marrow examination • What are the laboratory investigations you will do to arrive at a diagnosis and what are the expected results • What are the complications of this disease
15 Marks
2.(a) Define neoplasia. (b) Enumerate the four classes of normal regulatory genes, with one example each, that are the principal targets of genetic damage leading to carcinogenesis. (c) Write a note on how viruses are implicated in carcinogenesis with examples. (d) Tabulate the salient differences between benign and malignant tumors.
15 Marks
3.Name the different types of giant cells. How does a foreign body giant cell differ from tumor giant cell
8 Marks
4.Apoptosis in pathologic conditions
8 Marks
5.Biologic mechanism of Type II hypersensitivity reaction. Give examples of four diseases with type II hypersensitivity as the mechanism of pathologic injury
8 Marks
6.Laboratory diagnosis of megaloblastic anaemia
8 Marks
7.Define edema and describe the various pathogenetic mechanisms involved in different clinical situations associated with edema.
8 Marks
8.Differences between tuberculoid and lepromatous leprosy
4 Marks
9.Laboratory diagnosis of acute promyelocytic leukemia.
4 Marks
10.Differential diagnosis of pancytopenia.
4 Marks
11.Various adverse reactions of blood transfusion.
4 Marks
12.Nephrotic range proteinuria – Definition and common causes
4 Marks
13.Name the type of necrosis seen in infarcts.
1 Mark
14.Name a stain to demonstrate fungi in tissue.
1 Mark
15.What is Direct Coomb’s test.
1 Mark
16.The fixative used for surgical biopsy specimen is ______________________
1 Mark
17.What is the cytogenetic abnormality seen in Chronic Myeloid Leukemia
1 Mark
18.Low and fixed specific gravity of urine is seen in __________________
1 Mark
19.Name two opportunistic viral infection seen in AIDS.
1 Mark
20.The genetic defect in Gaucher disease is _______________________
1 Mark
21.Name two common causes for thrombocytopenia.
1 Mark
22.What is Barrett esophagus.
1 Mark

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