RGUHS MBBS Microbiology February 2023 (1030 CBME)

1030Rajiv Gandhi University of Health Sciences · Microbiology · 2023 · February · CBME

Questions (30)

1.Mr. A, 40 yrs old male presents with painful vesicular lesions on the trunk region. He informs the dermatologist that he is getting this for the second time in the same year. Haematological investigations revealed that he had leucopenia with lymphocytopenia. Tzanck smear from the vesicles showed cells with ground glass appearance. Further tests revealed that he was reactive to HIV a) What is the clinical condition the patient presented with? b) Draw a neat labelled diagram of HIV c) Discuss the laboratory diagnosis of HIV infection d) Add a note on the post-exposure prophylaxis against HIV after needle stick injury as per NACO guidelines
10 Marks
2.A 16 year old girl presented with fever, abdominal pain, loose stools with blood and mucus. Microscopic examination of stool showed many pus cells and non-motile bacilli a) Enumerate the causative agents of dysentery b) Discuss the pathogenesis and laboratory diagnosis of Shigellosis c) Compare and contrast Amoebic dysentery and Bacillary dysentery
10 Marks
3.Laboratory diagnosis of Malaria
5 Marks
4.Define cytokines and discuss their role in immune response
5 Marks
5.Give an outline of laboratory diagnosis of bacterial infections
5 Marks
6.Laboratory diagnosis of enteric fever
5 Marks
7.Discuss the mechanisms of drug resistance among bacteria with examples
5 Marks
8.Write briefly on Sporotrichosis
5 Marks
9.Delayed type hypersensitivity reaction
5 Marks
10.Etiopathogenesis and laboratory diagnosis of gas gangrene
5 Marks
11.Mention the markers for acute hepatitis B infection
3 Marks
12.Define transport media and mention its uses
3 Marks
13.DEC provocation test
3 Marks
14.Travellers diarrhoea
3 Marks
15.Chronic muco-cutaneous candidiasis
3 Marks
16.Draw a neat labelled diagram of fertilized ovum of Ascaris lumbricoides
3 Marks
17.Laboratory diagnosis of Leprosy
3 Marks
18.Graft versus host reaction
3 Marks
19.Name the three agents causing Mycetoma
3 Marks
20.Laboratory diagnosis of cholera
3 Marks
21.False statement about innate immunity is A. Acts as first line of defence B. Complement system plays role C. Nonspecific D. Immunological memory seen
1 Mark
22.The antibiotic that cannot be used for treatment of extended spectrum β-lactamase producing organisms A. Ceftriaxone B. Piperacillin – tazobactam C. Amikacin D. Meropenem
1 Mark
23.Active immunity is not acquired by A. Vaccination B. Immunoglobulin transfer C. Infection D. Vaccination and immunoglobulins
1 Mark
24.Floatation technique is useful for the detection of A. Larva of strongyloides B. Fertilised eggs of Ascaris lumbricoides C. Taenia eggs D. Operculated eggs of trematodes
1 Mark
25.A cook in a hostel mess suffered from enteric fever 2 years back. The chronic carrier state in this patient can be diagnosed by A. Widal test B. Blood culture C. Vi Antibody test D. Bone marrow culture
1 Mark
26.Which of the following is the most recommended method for diagnosis of pediatric HIV infection A. DNA PCR B. RNA PCR C. Real time PCR D. P24 antigen detection
1 Mark
27.The most common agent causing traveller’s diarrhoea is A. Enteroaggregative E.coli B. Norovirus C. Rotavirus D. Enterotoxigenic E.coli
1 Mark
28.False statement about hyper infection syndrome A. It is due to repeated autoinfection cycles B. Caused by Strongyloides stercoralis C. Seen in immunocompetent patients D. Causes enteritis or Malabsorption
1 Mark
29.Koplik’s spot in buccal mucosa is diagnostic of A. Mumps B. Measles C. Erythema infectiosum D. Rubella
1 Mark
30.The granules discharged in mycetoma contain A. Bone spicules B. Fungal colonies C. Pus cells D. Digested tissue
1 Mark

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