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RGUHS MBBS Microbiology April 2025 (1030 CBME)

1030Rajiv Gandhi University of Health Sciences · Microbiology · 2025 · April · CBME

Questions (30)

  1. 1.A 40-year-old-man presented to hospital with complaints of fever and weight loss. On examination, 102oF fever and anaemia were noted. Enlargement of liver and spleen were also present. The bone marrow aspirate collected was subjected to Giemsa staining which revealed amastigotes filled within a macrophage. a) Identify the etiological agent and the clinical diagnosis? b) Write about the life cycle & pathogenesis of the etiological agent. c) Describe the laboratory diagnosis of above condition.
    10 Marks
  2. 2.A 25-year-old-man complains of mild fever, abdominal cramps, tenesmus, frequent passage of stools associated with blood and mucus. Stool microscopy shows abundant pus cells and no ova/cysts/trophozoites were seen. Stool culture yielded the growth of non-lactose fermenters. a) What is the etiological agent causing above clinical condition? b) Describe the pathogenesis and complications of the above clinical condition c) Describe the laboratory diagnosis of the above clinical condition
    10 Marks
  3. 3.Describe passive immunity.
    5 Marks
  4. 4.Pathogenesis & prevention of tetanus.
    5 Marks
  5. 5.Laboratory diagnosis of HIV infection
    5 Marks
  6. 6.Molluscum contagiosum.
    5 Marks
  7. 7.Give an outline of laboratory diagnosis of fungal infections.
    5 Marks
  8. 8.Antibiotic associated diarrhoea.
    5 Marks
  9. 9.Discuss the clinical manifestations and laboratory diagnosis of sporotrichosis.
    5 Marks
  10. 10.Describe principle, types and applications of ELISA.
    5 Marks
  11. 11.Modified Jones criteria for diagnosis of rheumatic fever.
    3 Marks
  12. 12.Principle and uses of Widal test.
    3 Marks
  13. 13.Enumerate methods of Antimicrobial Susceptibility test.
    3 Marks
  14. 14.Write any three applications of PCR.
    3 Marks
  15. 15.Name three agents causing Mycetoma.
    3 Marks
  16. 16.Methods of HLA typing.
    3 Marks
  17. 17.Life cycle of Enterobius vermicularis.
    3 Marks
  18. 18.Modes of transmission of Hepatitis B Virus.
    3 Marks
  19. 19.Structure of IgA.
    3 Marks
  20. 20.Laboratory diagnosis of Chagas’ Disease
    3 Marks
  21. 21.The infective form of Balantidium coli is A. Cyst B. Sporozoite C. Trophozoite D. Tachyzoites
    1 Mark
  22. 22.All are heterophile antigen test EXCEPT A. Paul- Bunnell test B. Weil- Felix test C. Cold Agglutination Test D. Rose -Waaler test
    1 Mark
  23. 23.Hair perforation test is positive in one of the following dermatophytes; A. Trichophyton rubrum B. Trichophyton mentagrophytes C. Trichophyton tonsurans D. Trichophyton violaceum
    1 Mark
  24. 24.Traveler’s diarrhea is caused by A. Enterohemorrhagic E.coli B. Enteropathogenic E. coli C. Enterotoxigenic E. coli D. Enteroinvasive E.coli
    1 Mark
  25. 25.Hand –foot and mouth disease is caused by A. Herpes Simplex virus B. Coxsackie virus C. Measles virus D. Chicken pox virus
    1 Mark
  26. 26.In which phase of bacterial growth curve sporulation occurs A. Lag Phase B. Log Phase C. Phase of decline D. Stationary Phase
    1 Mark
  27. 27.Which hepatitis virus is associated with the highest mortality in pregnancy? A. Hepatitis E Virus B. Hepatitis C Virus C. Hepatitis B Virus D. Hepatitis A Virus
    1 Mark
  28. 28.Which of the following clinical sample is NOT suitable for anaerobic infections? A. Swabs B. Tissue bit C. Necrotic material D. Aspirates in air tight container
    1 Mark
  29. 29.Which bacterial spores are used as sterilization control in autoclave? A. Clostridium perfringens B. Bacillus cereus C. Geobacillus stearothermophilus D. Pseudomonas aeruginosa
    1 Mark
  30. 30.Babesiosis is transmitted by A. Mites B. Ticks C. Flea D. Mosquito
    1 Mark

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