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RGUHS MBBS Microbiology November 2025 (1030 CBME)

1030Rajiv Gandhi University of Health Sciences · Microbiology · 2025 · November · CBME

Questions (30)

  1. 1.An adult man presented with intermittent fever, loss of appetite and pain abdomen since 8 days. On examination he is febrile and spleen is palpable. Titres obtained in Widal test are O=80, H=160, AH=<20 and BH=<20. a) Identify the causative agent b) Describe laboratory diagnosis of this condition during different phases of infection c) Suggest methods to prevent this infection
    10 Marks
  2. 2.A truck driver with history of exposure to multiple sex workers presents with loss of weight for the past three months and on investigation he is reactive for HIV-1. a) Draw neat labelled diagram of HIV virus b) Discuss the different modes of transmission of HIV and measures to prevent this condition c) Discuss the different NACO strategies for the laboratory diagnosis
    10 Marks
  3. 3.Antibiotic susceptibility testing methods for bacteria
    5 Marks
  4. 4.Mention different types of graft rejection and suggest measures to prevent rejection
    5 Marks
  5. 5.a. Mention the differences between innate and acquired immunity
    5 Marks
  6. 6.A boy has intermittent fever with chills and rigors since 5 days. His spleen is enlarged and palpable. Peripheral blood smear showed ring-shaped structures inside the RBCs. Describe the life cycle and outline the laboratory diagnosis
    5 Marks
  7. 7.An elderly man has painful erythematous mucosa of oral cavity and tongue, covered with white patches. Gram positive budding yeast-like organism was demonstrated in the swab taken from patch. Describe etiopathogenesis and laboratory diagnosis of this condition
    5 Marks
  8. 8.b. Pathogenesis and laboratory diagnosis of Hepatitis A
    5 Marks
  9. 9.c. Mycetoma
    5 Marks
  10. 10.d. Mucor mycosis
    5 Marks
  11. 11.Transduction and its implications
    3 Marks
  12. 12.Ethylene oxide sterilisation (ETO)
    3 Marks
  13. 13.Chemiluminescence assay (CLIA)
    3 Marks
  14. 14.Laboratory diagnosis of Kala azar
    3 Marks
  15. 15.Mention three sepsis markers
    3 Marks
  16. 16.Name three causes of dysentery
    3 Marks
  17. 17.Draw a labelled diagram of ovum of Ascaris lumbricoides
    3 Marks
  18. 18.Piedra
    3 Marks
  19. 19.Name three atypical mycobacteria causing skin lesions
    3 Marks
  20. 20.Name the hosts involved in life cycle of dracunculiasis
    3 Marks
  21. 21.Motility of spirochetes is because of A. Peritrichous flagella B. Endoflagella C. Special fimbriae D. Flexible cell walls
    1 Mark
  22. 22.Inclusion bodies are seen in the following conditions EXCEPT A. Rabies B. Herpes C. Yellow fever D. HIV
    1 Mark
  23. 23.False about herd immunity is A. It is pathogen-specific B. Depends upon the population composition C. Completely a natural phenomenon D. Determines occurrence of epidemics in the population
    1 Mark
  24. 24.True about hapten is A. Molecular weight higher than that of simple antigens B. Lack immunogenicity C. Not capable of immunological reactivity D. Always protein in nature
    1 Mark
  25. 25.NOT a professional antigen presenting cell is A. Macrophage B. Dendritic cell C. B lymphocyte D. T lymphocyte
    1 Mark
  26. 26.Antigenic cross-reactivity between Streptococcal antigen and corresponding human antigen is the underlying mechanism in rheumatic fever. The correct combination of cross-reacting antigens is A. Hyaluronic acid – skin antigen B. Cytoplasmic membrane – synovial tissue C. Cell wall C antigen – Cardiac wall D. M protein – glomerular vascular intima
    1 Mark
  27. 27.A diabetic patient with polytrauma with multiple infected wounds is admitted in the hospital for one month and received multiple antibiotics. He develops diarrhea and colonoscopy showed membranous patches. Most probable causative agent is A. Corynebacterium diphtheriae B. Enteroaggregative Escherichia coli C. Clostridioides difficile D. Candida albicans
    1 Mark
  28. 28.NOT suitable for diagnosis of enterobiasis is A. Demonstration of adult worm in clothes B. NIH swab C. Microscopy of freshly passed stool D. Perianal cellophane tape mount
    1 Mark
  29. 29.Cystic lesion in liver of a veterinarian, showed brood capsules and protoscolices under the microscopy. The probable organism is A. Entamoeba histolytica B. Echinococcus granulosus C. Faciola hepatica D. Schistosoma japonicum
    1 Mark
  30. 30.A girl aged 4 years has rashes on the skin along with fever. Rashes are centripetally distributed. Rashes appeared in crops and have macules, papules, vesicles, pustules and scabs. The girl had most probably acquired the infection by A. Aerosols B. Insect bite C. Ingestion D. None of the above
    1 Mark

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