RGUHS MBBS Pathology January 2024 (1026 CBME)

1026Rajiv Gandhi University of Health Sciences · Pathology · 2024 · January · CBME

Questions (30)

1.10 year old male presented with pain abdomen, fever and vomiting of one day duration. On examination there is tenderness over Mcburney’s point. Ultrasound examination of the abdomen showed evidence of dilated appendix. a) What type of inflammation is seen in this condition? b) Discuss the cellular events occurring in this condition c) List the chemical mediators that facilitate the cellular events
10 Marks
2.13 year old male has sudden onset of severe abdominal pain and cramping accompanied by chest pain, non productive cough, pain in the bones of the hand and fever. Physical examination revealed that his temperature is 39C and pulse rate is 110/min. He has diffuse abdominal tenderness and spleenomegaly. Lab studies show haematocrit of 18% and peripheral smear showed sickle shaped cells. X ray chest showed bilateral pulmonary infiltrates a) Discuss the pathogenesis of the sudden onset symptoms in the child b) Discuss the laboratory investigations relevant to the history provided
10 Marks
3.1. Microscopic variants of Hodgkins Lymphoma.
5 Marks
4.2. Enumerate the steps in the investigations of the transfusion reaction.
5 Marks
5.3. Define necrosis. Discuss various types of necrosis with examples.
5 Marks
6.Paraneoplastic syndrome.
5 Marks
7.Type I hypersensitivity.
5 Marks
8.Chemical carcinogenesis.
5 Marks
9.Etiopathogenesis of Septic shock.
5 Marks
10.Define hypertrophy. Discuss the types of hypertrophy with their mechanism.
5 Marks
11.Draw labelled diagram of fatty liver.
3 Marks
12.List any three tumour suppressor genes.
3 Marks
13.Stains for amyloidosis.
3 Marks
14.Packed cell volume.
3 Marks
15.Define granuloma and draw a neat diagram.
3 Marks
16.Differences between transudate and exudate.
3 Marks
17.Exfoliative cytology.
3 Marks
18.Fate of thrombus.
3 Marks
19.Draw peripheral smear picture of Megaloblastic anaemia.
3 Marks
20.Causes of Thrombocytopenia.
3 Marks
21.All are chemical mediators of acute inflammation EXCEPT A. Histamine B. Prostaglandin C. Leukotrienes D. Progesterone
1 Mark
22.50 year old male presents with breathlessness and weight loss. Imaging revealed nodular lesion in the left lung lower lobe. Biopsy shows an adenocarcinoma. Which of the following is the likely mutation associated with this condition? A. EGFR mutation B. PTEN mutation C. BCL2 mutation D. APC mutation
1 Mark
23.Ghon’s complex comprises of which one of the following A. Hilar lymphadenopathy B. Apical fibrocavitatory lesion C. Miliary lesions across bilateral lungs D. Progressive primary lesions
1 Mark
24.Down’s syndrome is due to A. Trisomy 22 B. Trisomy 21 C. Trisomy 18 D. Trisomy 20
1 Mark
25.63 year old male hypertensive develops paralysis of the right side of the body. Which of the following patterns of tissue injury is likely to be present in the brain after 4-5 days? A. Fat necrosis B. Caseous necrosis C. Coagulated necrosis D. Liquefactive necrosis
1 Mark
26.Acute promeylocytic leukemia characteristically shows presences of Auer rods in the blast. Which of the following stains highlight these Auer rods A. Verhoff stain B. Myeloperoxidase C. PAS D. Glial fibrillary acidic protein
1 Mark
27.70 year old male presented with worsening heart failure. Echocardiogram showed cardiomegaly with four chamber dilatation. Which type of amyloid is likely to be present in the heart A. SAA B. Transthyretin C. AL D. Beta2 microglobulin
1 Mark
28.ESR is markedly raised in A. Multiple myeloma B. Malaria C. Acute myeloblastic leukemia D. Haemophilia
1 Mark
29.Howell Jolly bodies are seen in A. Myeloblasts B. Lymphoblasts C. Megaloblasts D. Sickle cell
1 Mark
30.Neutrophilia is typically seen in A. Acute bacterial infections B. Typhoid C. Malaria D. Infectious mononucleosis
1 Mark

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