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RGUHS MBBS Pathology April 2025 (1026 CBME)

1026Rajiv Gandhi University of Health Sciences · Pathology · 2025 · April · CBME

Questions (30)

  1. 1.65 year old male, known case of interstitial lung disease and pulmonary hypertension is brought to the emergency department with decreased urine output and altered sensorium. On examination pulse is 123 beats/min, BP- 96/60 mmhg, RR-28cycles/min with cold extremities. a. What is the probable clinical diagnosis? b. Discuss the pathogenesis and various organ changes. c. Enumerate the laboratory findings.
    10 Marks
  2. 2.28 year old female presented with history of menorrhagia. She gives history of fever 15days back. On examination pallor and petechiae present. No splenomegaly. CBC reveals Hemoglobin- 7.6 gm/dl, WBC count- 6000 cells/cumm, Platelet- 28,000/cumm. a. What is the clinical diagnosis and why? b. Discuss the etiopathogenesis of the above condition c. Enumerate the lab findings investigations
    10 Marks
  3. 3.Describe the various vascular events involved in acute inflammation.
    5 Marks
  4. 4.Discuss antibody mediated hypersensitivity with examples.
    5 Marks
  5. 5.Define Hyperplasia. Briefly discuss the pathogenesis
    5 Marks
  6. 6.Describe urinary Casts with a neat diagram.
    5 Marks
  7. 7.List the difference between leukemoid reaction and chronic myeloid leukemia.
    5 Marks
  8. 8.Pathology and laboratory diagnosis of Hereditary spherocytosis
    5 Marks
  9. 9.Paraneoplastic syndromes.
    5 Marks
  10. 10.Role of p53 in carcinogenesis.
    5 Marks
  11. 11.Morphology of caseous necrosis
    3 Marks
  12. 12.Bone marrow findings in megaloblastic anemia.
    3 Marks
  13. 13.Microscopy of neuroblastoma.
    3 Marks
  14. 14.CSF findings in tuberculous meningitis.
    3 Marks
  15. 15.Cerebral malaria.
    3 Marks
  16. 16.Bombay blood group.
    3 Marks
  17. 17.Chemokines.
    3 Marks
  18. 18.Dystrophic Calcification.
    3 Marks
  19. 19.Three causes of target cells in peripheral smear.
    3 Marks
  20. 20.Enumerate neoplasms found in patients with HIV infection.
    3 Marks
  21. 21.All of the following are powerful antioxidant EXCEPT A. Superoxide dismutase B. Ceruloplasmin C. Transferin D. Nitric oxide synthase
    1 Mark
  22. 22.Prolonged production of Acute phase proteins in chronic infection can cause A. Amyloidosis B. SLE C. Myocardial infarction D. Rheumatoid arthritis
    1 Mark
  23. 23.A decrease in organ size(atrophy) may be result of each of the following EXCEPT A. Lack of innervation B. Ageing C. Metabolic storage disorder D. Reduction of hormone stimulation
    1 Mark
  24. 24.A 30 year old woman got a cut on her finger while cutting vegetables. On examination the wound was clean and approximated with the help of sutures. By what day would you expect to see the formation of granulation tissue in this type of healing? A. Day 1-3 B. Day 3-5 C. Day 5-7 D. After 1 week
    1 Mark
  25. 25.Vitamin K dependent clotting factors include all EXCEPT A. Factor VII B. Factor IX C. Factor XI D. Factor X
    1 Mark
  26. 26.Which of the following is matched correctly A. Huntington’s disease- Autosomal recessive B. Familial hypercholesterolemia- X linked recessive C. Marfan syndrome- X linked dominant D. Alkaptonuria- Autosomal recessive
    1 Mark
  27. 27.EBV induced Burkitt’s lymphoma causes following translocation A. 14:8 B. 18:4 C. 8:14 D. 4:18
    1 Mark
  28. 28.All are examples of tumour suppressor genes implicated in human cancer EXCEPT A. RB gene B. RET C. APC D. Tp-53
    1 Mark
  29. 29.Most common presentation of paraneoplastic syndrome is A. Hypercalcemia B. Acanthosis nigricans C. Cushing’s syndrome D. Hypoglycemia
    1 Mark
  30. 30.Lead poisoning produces following change in RBC’s A. Pappenheimer bodies B. Heinz bodies C. Howell-Jolly bodies D. Basophilic stippling
    1 Mark

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