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RGUHS MBBS Pharmacology June 2024 (1028 CBME)

1028Rajiv Gandhi University of Health Sciences · Pharmacology · 2024 · June · CBME

Questions (30)

  1. 1.Define Drug antagonism. Discuss the different types of drug antagonism with suitable examples.
    10 Marks
  2. 2.A 75 year old patient presents with defective gait and posture, mask like face and Sialorrhoea. On examination, he had rigidity, tremors and hypokinesia. He was diagnosed to be suffering from Parkinsonism. a) Classify Antiparkinsonian drugs with suitable examples b) Discuss the Pharmacological actions and adverse effects of Levodopa
    10 Marks
  3. 3.Therapeutic uses and adverse effects of Alpha Blockers
    5 Marks
  4. 4.Define Bioavailability of a drug. Explain four drug related factors affecting bioavailability
    5 Marks
  5. 5.Cardiovascular actions of Adrenaline
    5 Marks
  6. 6.Compare and contrast Physostigmine and Neostigmine
    5 Marks
  7. 7.Pharmacological actions and adverse effects of Aspirin
    5 Marks
  8. 8.Inhalational glucocorticoids in Bronchial asthma
    5 Marks
  9. 9.A 38 year old patient after surgery for fracture femur is given Metoclopramide for antiemetic action. a) Explain the rationale of using metoclopramide in this patient. b) Write its adverse effects and uses.
    5 Marks
  10. 10.A 30 year old patient is brought to hospital with delusional beliefs, auditory hallucinations, restlessness, disturbed sleep and inappropriate behaviour. She was diagnosed to be suffering from schizophrenia and prescribed Olanzapine. a) Explain the rationale of using Olanzapine in this patient. b) Write its advantages over conventional antipsychotics.
    5 Marks
  11. 11.What is therapeutic drug monitoring (TDM)? Write two drugs requiring TDM
    3 Marks
  12. 12.Rationale of using Atropine in Organophosphorous compound poisoning
    3 Marks
  13. 13.Rationale of using Morphine in acute pulmonary oedema
    3 Marks
  14. 14.Write two adverse effects of Phenytoin. Why is phenytoin contraindicated in pregnancy?
    3 Marks
  15. 15.Write three nondepolarising skeletal muscle relaxants
    3 Marks
  16. 16.Name two anti-motility drugs. Why are they contraindicated in Shigella dysentery?
    3 Marks
  17. 17.Write Two advantages and Two disadvantages of selective Cox 2 inhibitors
    3 Marks
  18. 18.Name three antitussives
    3 Marks
  19. 19.Explain the concept of Essential medicines (drugs)
    3 Marks
  20. 20.Write three uses of Calcium Disodium edetate
    3 Marks
  21. 21.An 18 year old female patient is brought to hospital in an unconscious state following accidental drug overdose. Which of the following route is desirable for administering the antidote for this patient? A. Oral B. Transdermal C. Intravenous D. Subcutaneous
    1 Mark
  22. 22.Which of the following is a prodrug? A. Hydralazine B. Levodopa C. Paracetamol D. Aspirin
    1 Mark
  23. 23.Apraclonidine is a congener of clonidine used for A. Pain relief B. Reducing Blood pressure C. Reducing intraocular tension D. Reducing blood glucose
    1 Mark
  24. 24.Atropine produces all the following actions EXCEPT A. Tachycardia B. Dryness of mouth C. Mydriasis D. Urinary incontinence
    1 Mark
  25. 25.A 8 year old boy was brought by the mother with momentary loss of consciousness. EEG shows spike and wave pattern. Pediatrician made a diagnosis of absence seizures. Which of the following drug is useful for absence seizures? A. Phenobarbitone B. Sodium Valproate C. Phenytoin D. Carbamazepine
    1 Mark
  26. 26.Which of the following antipsychotic produces extrapyramidal side effects? A. Chlorpromazine B. Olanzapine C. Quetiapine D. Aripiprazole
    1 Mark
  27. 27.Which antihistaminic drug produces less central nervous system depressant activity? A. Diphenhydramine B. Pheniramine C. Promethazine D. Cetrizine
    1 Mark
  28. 28.Which of the following drug cannot be administered by inhalational route in asthma A. Montelukast B. Ipratropium bromide C. Budesonide D. Salbutamol
    1 Mark
  29. 29.An anti-emetic can be used in a conscious patient suffering from poisoning due to all the following EXCEPT A. Iron B. Diazepam C. Kerosene D. Paracetamol
    1 Mark
  30. 30.Essential drugs are A. Life saving drugs B. Inert drugs C. Drugs that meet the priority health care needs of the population D. Drugs that have no therapeutic use
    1 Mark

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