RGUHS MBBS Pharmacology December 2024 (1029 CBME)

Questions (30)

1. 1.a) Enlist different groups of Semisynthetic Penicillins giving one example for each b) Write the mechanism of action, uses and adverse effects of Amoxicillin
   10 Marks
2. 2.A 14 year old thinly built boy presented with polydipsia, polyphagia, polyuria, fatigue and weakness. His Fasting blood Sugar was 198 mg/dl, Post prandial blood sugar was 225 mg/dl, HbA1c was 9%. He is diagnosed to be suffering from Insulin dependent diabetes mellitus. a) Classify Insulin preparations based on their duration of action b) Discuss the Uses and adverse effects of Insulin
   10 Marks
3. 3.Mechanism of action, advantages and adverse effects of Angiotensin converting enzyme inhibitors (ACE inhibitors)
   5 Marks
4. 4.a) Enumerate the advantages of Low molecular weight heparins
   5 Marks
5. 5.Compare and contrast Propylthiouracil and Carbimazole
   5 Marks
6. 6.A surgeon sustained a needle stick injury while operating, following which, the patient was tested for HIV which was reported as positive. a) Mention one drug regimen used for post exposure prophylaxis of HIV infection b) What is the time limit to initiate therapy?
   5 Marks
7. 7.Mechanism of action, uses and adverse effects of Methotrexate
   5 Marks
8. 8.A 65 year old patient admitted with Myocardial infarction complains of breathlessness, worse on lying down, cough with blood tinged sputum. The physician made a diagnosis of acute pulmonary oedema and decided to administer Furosemide. Describe the mechanism of action, uses and adverse effects Furosemide
   5 Marks
9. 9.Mechanism of action and uses of Digoxin
   5 Marks
10. 10.Adverse effects and contraindications of Oral contraceptive pills
    5 Marks
11. 11.Name Three Oral Iron preparations
    3 Marks
12. 12.Mention the advantages of Liposomal Amphotericin B preparation
    3 Marks
13. 13.Write two uses of tetracyclines. Why tetracyclines are contraindicated in young children?
    3 Marks
14. 14.Mention two adverse effects of INH? Rationale of combining INH with pyridoxine?
    3 Marks
15. 15.Mention three uses of Chloroquine other than malaria.
    3 Marks
16. 16.Name three fat soluble vitamins.
    3 Marks
17. 17.Name two statins. Explain why is it beneficial to take statins in the Night?
    3 Marks
18. 18.Write Three advantages of Azithromycin over Erythromycin?
    3 Marks
19. 19.Rationale of using Nitrates in Cyanide poisoning
    3 Marks
20. 20.Mention three drugs used in Lepra reactions.
    3 Marks
21. 21.A woman in the 28th week of pregnancy has developed pregnancy induced hypertension. Her blood pressure is150/100 mm Hg. Select the most appropriate antihypertensive drug for her A. Furosemide B. Methyldopa C. Propranolol D. Captopril
    1 Mark
22. 22.Which of the following is an Inodilator used in Heart failure? A. Dobutamine B. Milrinone C. Ephedrine D. Phenylephrine
    1 Mark
23. 23.Diuretics are suitable antihypertensives in patients with coexisting A. Gout B. Dyslipidemia C. Isolated systolic Hypertension D. Pregnancy induced Hypertension
    1 Mark
24. 24.Which of the following is a non-cardiac use of Nifedipine A. Tocolytic B. Glaucoma C. Thyroid storm D. Essential tremor
    1 Mark
25. 25.Drug used for delaying labour is A. Ergometrine B. Ritodrine C. Oxytocin D. Propranolol
    1 Mark
26. 26.Bisphosphonates are indicated in the following condition A. Pemphigus B. Epilepsy C. Steven’s Johnson syndrome D. Osteoporosis
    1 Mark
27. 27.Which of the following inhibits bacterial protein synthesis? A. Penicillins B. Erythromycin C. Cephalosporins D. Vancomycin
    1 Mark
28. 28.All the following antibiotics are obtained from fungi EXCEPT A. Penicillin B. Cephalosporin C. Griseofulvin D. Colistin
    1 Mark
29. 29.Which of the following Aminoglycoside is a first line anti-tubercular drug A. Kanamycin B. Gentamicin C. Streptomycin D. Netilmycin
    1 Mark
30. 30.Anti-cancer drug that causes disruption of mitotic spindle A. 6-Mercaptopurine B. Cisplatin C. Methotrexate D. Vincristine
    1 Mark

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