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RGUHS MBBS Pharmacology June 2024 (1029 CBME)

1029Rajiv Gandhi University of Health Sciences · Pharmacology · 2024 · June · CBME

Questions (30)

  1. 1.Classify Penicillins. Describe the mechanism of action, adverse effects and therapeutic uses of Benzyl Penicillin
    10 Marks
  2. 2.A 58 year old known diabetic was brought to hospital with mental confusion, vomiting, pain abdomen and rapid breathing. He had fruit scented breath. His Random blood sugar was 320 mg/dl with ketone bodies in the urine. He was diagnosed to be suffering from Diabetic ketoacidosis. a) Outline the management of this patient b) Mention the adverse effects of Insulin c) Enumerate the therapeutic uses of Insulin
    10 Marks
  3. 3.1. Mechanism of action, therapeutic uses and adverse effects of Rifampicin
    5 Marks
  4. 4.2. Therapeutic uses of Glucocorticoids
    5 Marks
  5. 5.Mechanism of action, Advantages and Disadvantages of Radioactive Iodine
    5 Marks
  6. 6.Pharmacological actions, Uses and adverse effects of Nifedipine
    5 Marks
  7. 7.Mechanism of action, therapeutic uses and adverse effects of Vinca Alkaloids
    5 Marks
  8. 8.Role of Nitroglycerine in the management of Myocardial Infarction
    5 Marks
  9. 9.A 78 year old patient presents to hospital with pain and swelling in the calf region of right leg. He was bed ridden for 3 months following a surgery. Detailed investigation revealed Deep vein thrombosis. After initial therapy with Heparin, he was discharged with a prescription of Warfarin. a) What is the rationale of using Warfarin in this patient? b) List the adverse effects and therapeutic uses of Warfarin.
    5 Marks
  10. 10.A 70 year old male presents to hospital with acute breathlessness. He has pedal oedema, engorged neck and distended abdomen. A diagnosis of heart failure was made. Frusemide was administered to this patient. a) Explain the rationale of using frusemide in this patient. b) Enumerate its adverse effects and other therapeutic uses.
    5 Marks
  11. 11.Mention three uses of Dapsone
    3 Marks
  12. 12.Rationale of combining Trimethoprim with Sulfamethoxazole
    3 Marks
  13. 13.Why Tetracyclines are contraindicated in pregnancy?
    3 Marks
  14. 14.Mention three advantages of Azithromycin over Erythromycin
    3 Marks
  15. 15.Rationale of using Vancomycin in Pseudomembranous enterocolitis. Write two other uses of Vancomycin.
    3 Marks
  16. 16.Mention three drugs used in Acne Vulgaris
    3 Marks
  17. 17.Mention three Advantages of Albendazole over Mebendazole
    3 Marks
  18. 18.Mention three advantages of Low molecular weight Heparins
    3 Marks
  19. 19.Write two uses of Enalapril. Why Enalapril is contraindicated in pregnancy?
    3 Marks
  20. 20.Write three indications for parenteral Iron therapy
    3 Marks
  21. 21.The following drug improves urine outflow in patients with benign prostatic hypertrophy A. Nifedipine B. Prazosin C. Atenolol D. Methyldopa
    1 Mark
  22. 22.Rebound hypertension on sudden withdrawal of medication is associated with A. Hydrochlorothiazide B. Prazosin C. Clonidine D. Lisinopril
    1 Mark
  23. 23.Antidote for Heparin overdose is A. Sodium sulfate B. Magnesium sulfate C. Protamine sulfate D. Copper sulfate
    1 Mark
  24. 24.Hydrochlorothiazide can cause A. Hearing loss B. Hyperkalemia C. Hypocalcemia D. Hyperglycemia
    1 Mark
  25. 25.Rapid Acting Insulin is A. Insulin Glargine B. Insulin Detemir C. Insulin Lispro D. Insulin Degludec
    1 Mark
  26. 26.Hypothalamo pituitary-adrenal axis suppression during long-term steroid therapy can be minimised by all the following measures EXCEPT A. Use of long acting steroids B. Use of steroids on alternate days C. Use of steroids for shortest duration D. Administering entire daily dose in the morning
    1 Mark
  27. 27.A premature neonate suffering from a respiratory infection received high doses of an antibiotic. Over the next two days his condition worsened, he became dull, stopped feeding, developed abdominal distention, became hypotonic and hypothermic. An ashen gray cyanosis developed. A diagnosis of Gray baby syndrome was made. Which of the following antimicrobial agent is responsible for this neonatal syndrome: A. Ampicillin B. Chloramphenicol C. Erythromycin D. Ciprofloxacin
    1 Mark
  28. 28.In the multidrug therapy of leprosy, Rifampin is given A. Daily B. On alternate days C. Weekly D. Monthly
    1 Mark
  29. 29.Folinic acid is used in the treatment of toxicity due to A. Methotrexate B. Digoxin C. Cyclophosphamide D. Iron
    1 Mark
  30. 30.Chloroquine is used in all the following conditions EXCEPT A. Malaria B. Extraintestinal Amoebiasis C. Rheumatoid arthritis D. Filariasis
    1 Mark

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