RGUHS MBBS Pharmacology April 2025 (1029 CBME)

1029Rajiv Gandhi University of Health Sciences · Pharmacology · 2025 · April · CBME

Questions (30)

1.a) Discuss the endocrinal and non-endocrinal uses of corticosteroids. b) Write the measures to minimize HPA axis (hypothalamic–pituitary–adrenal axis) suppression during corticosteroid therapy.
10 Marks
2.A 48 year old executive was diagnosed with essential hypertension during his annual health screening. He was prescribed Angiotensin Converting Enzyme Inhibitors (ACEIs). a) Enumerate four ACEIs. b) Write the mechanism of action, uses and adverse effects of ACEIs.
10 Marks
3.Discuss the advantages and disadvantages of combined use of Antimicrobials.
5 Marks
4.Mention three Artemisinin-based Combination Therapy (ACT) regimens for uncomplicated falciparum malaria. Discuss the advantages of ACT regimens.
5 Marks
5.Write the mechanism of action, uses and adverse effects of Dapsone.
5 Marks
6.Discuss the general toxicities of Anticancer drugs.
5 Marks
7.Write the mechanism of action, advantages and disadvantages of Radioactive Iodine
5 Marks
8.A 20-year-old student with Type 1 Diabetes mellitus presenting to hospital was diagnosed with diabetic ketoacidosis. Explain the pharmacotherapy of diabetic ketoacidosis.
5 Marks
9.Explain the mechanism of action, uses and adverse effects of Organic nitrates
5 Marks
10.A 50-year-old patient was diagnosed with pulmonary embolism in the hospital. He was started on Heparin infusion. Write the rationale of using Heparin in this patient. Write the uses and adverse effects of Heparin.
5 Marks
11.Explain the rationale of using Digoxin in heart failure
3 Marks
12.List two Plasma expanders with their indications
3 Marks
13.Mention two thiazide diuretics. Explain the rationale of using thiazide diuretics in nephrogenic diabetes insipidus
3 Marks
14.Explain the rationale of combining Amoxicillin with Clavulanic acid
3 Marks
15.Write three uses of Cotrimoxazole
3 Marks
16.Write the goals of antibiotic stewardship program in a hospital
3 Marks
17.Write three advantages of Azithromycin over Erythromycin
3 Marks
18.Write three advantages of Liposomal Amphotericin B
3 Marks
19.List three different groups of antimicrobials used in typhoid fever
3 Marks
20.List three different preparations of Vitamin-D
3 Marks
21.The oral antidiabetic agent that rarely causes hypoglycemia is A. Metformin B. Glimepiride C. Glibenclamide D. Tolbutamide
1 Mark
22.One of the following statements is TRUE regarding Octreotide A. Stimulate growth hormone secretion B. Used in secretory diarrheas associated with Carcinoid C. Contraindicated in Acromegaly D. Given by oral route
1 Mark
23.The Calcium channel blocker with anti-arrhythmic action is A. Nifedipine B. Nicardipine C. Amlodipine D. Verapamil
1 Mark
24.The drug which is a potassium channel opener and nitric oxide donor is A. Trimetazidine B. Nicorandil C. Diltiazem D. Sodium nitroprusside
1 Mark
25.Severe bleeding caused by fibrinolytic agents is preferably treated with A. Vitamin K B. Heparin C. Aspirin D. Epsilon aminocaproic acid
1 Mark
26.Which of the following is Potassium sparing diuretic? A. Furosemide B. Spironolactone C. Acetazolamide D. Hydrochlorothiazide
1 Mark
27.Which one of the following Antitubercular drug is known to cause visual defects A. Isoniazid B. Rifampicin C. Pyrazinamide D. Ethambutol
1 Mark
28.The anti-influenza drug that acts by inhibiting the viral neuraminidase enzyme is A. Acyclovir B. Oseltamivir C. Adefovir D. Nevirapine
1 Mark
29.The antineoplastic drug which is a mitotic inhibitor and causes metaphase arrest is A. Procarbazine B. Doxorubicin C. Vincristine D. Methotrexate
1 Mark
30.The drug preferred in the treatment of psoriasis is A. Calcipotriol B. Mupirocin C. Miconazole D. Silver sulfadiazine
1 Mark

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