Kaloji Narayana Rao University of Health Sciences Bachelor of Medicine and Bachelor of SurgeryPharmacology Previous Year Question Papers

Diuretic that can be used in renal failure a) Spironolactone b) Furosemide c) Mannitol d) Hydrochlorothiazide

The following analgesic lacks anti-inflammatory action: a) Paracetamol b) Ibuprofen c) Diclofenac sodium d) Piroxicam

Drugs acting via tyrosine kinase receptors are a) TRH b) TSH c) Insulin d) MSH

Adverse effects of Amiodarone include all except a) Photosensitization b) Nephrotoxicity c) Pulmonary Fibrosis d) Hypothyroidism

Superinfection is commonly seen in all of the following conditions except a) use of broad-spectrum antibiotics b) use of immunosuppressant drugs c) Nutritional deficiency d) diabetes mellitus

Mesna is administered with cyclophosphamide and Iphosphamide to: a) Potentiate their cytotoxic action b) Retard their renal excretion c) Block their emetic action d) Ameliorate cystitis caused by them

The drug which undergoes 'Hofmann' elimination is: a) Succinylcholine b) Pancuronium c) Vecuronium d) Atracurium

Therapeutic Index is a) ED50/LD50 b) ED50-LD50 c) LD50/ED50 d) ED50XLD50

Finasteride acts by: a) Blocking testosterone receptors in the prostate gland b) Reducing testosterone secretion from testes c) Reducing LH secretion from pituitary d) Lowering circulating as well as prostatic dihydrotestosterone concentration

Octreotide is a long-acting synthetic analogue of: a) Prolactin b) Growth hormone c) Somatostatin d) Gonadotropin releasing hormone

Cinchonism is caused by a) Quinine b) Artemether c) Mefloquine d) Chloroquine

fomepizole is used in which poisoning a) methyl alcohol poisoning b) morphine poisoning c) strychnine poisoning d) atropine poisoning

The dose of Pralidoxime and Atropine in treatment of OP poisoning are a) Pralidoxime 2gm and Atropine 2 mg b) Pralidoxime 2mg and Atropine 0.2 mg c) Pralidoxime 2gm and Atropine 1.2 mg d) Pralidoxime 2gm and Atropine 0.2 mg

Actions of bradykinin include the following except: a) Fall in blood pressure b) Cardiac depression c) Increase in capillary permeability d) Bronchoconstriction

All are aminoglycosides except a) Neomycin b) Azithromycin c) streptomycin d) Amikacin

Atropine poisoning causes all except a) Dilated pupil b) Excessive salivation c) Excitement d) hot skin

True statement regarding depolarising neuromuscular blocking drug is a) The depolarised muscle fibres are unresponsive to other stimuli b) Causes muscle Fasciculations c) Not reversed by neostigmine d) All of the above

The characteristic toxicity of Ethambutol is: a) Hepatitis b) Visual defects c) Vestibular disturbance d) Renal damage

Recombinant human erythropoietin is indicated for: a) Megaloblastic anaemia b) Haemolytic anaemia c) Anaemia in patients of tha1assemia d) Anaemia in chronic renal failure patients

Which of the following has a long post antibiotic effect a) Doxorubicin b) Aminoglycosides c) Sulfonamides d) All of the above

Antidote for paracetamol poisoning is a) Naloxone b) Methylene blue c) N-acetylcysteine d) Flumazenil

Superinfections in patients on steroids is what type of ADR? a) Side effect b) Secondary effect c) Idiosyncrasy d) Otoxic effect

The following is true of cyclophosphamide except: a) It is highly reactive and a vesicant on contact b) It is a prodrug c) It has marked immunosuppressant property d) It frequently causes alopecia and cystitis

Trimethoprim inhibits bacteria without affecting mammalian cells because: a) It does not penetrate mammalian cells b) It has high affinity for bacterial but low affinity for mammalian dihydrofolate reductase enzyme c) It inhibits bacterial folate synthetase as well as dihydrofolate reductase enzymes d) All of the above

Which of the following antimalarial agents are safe in pregnancy for a) Chloroquine b) Quinine c) Artesunate d) All of the above

The drug of choice for status epilepticus is a) Lorazepam b) Propofol c) Thiopentone d) Sodium valproate

After taking some drug for acute migraine, the patient developed nausea and vomiting, he also developed tingling and numbness in the tip of the finger which eventually turned blue. Which drug has caused it? a) Dihydroergotamine b) Sumatriptan c) Aspirin d) Butorphanol

All are contraindications to BCG vaccine except: a) Patients receiving Cancer therapy b) Pregnancy c) Individuals with compromised host defence d) Tuberculin positive individuals

Which of the following are antioxidant vitamins that help in prevention of cardiovascular disease and cancer? a) Vitamin E b) Beta carotene c) Vitamin C d) All of the above

All are antiplatelet drugs except a) Aspirin b) Warfarin c) clopidogrel d) dipyridamole

a) Enlist the different types of receptors with examples of drugs acting through them. b) Describe the factors modifying drug action and their clinical significance.

Classify Adrenergic drugs. Explain the pharmacological actions of Adrenaline. Mention the therapeutic uses and adverse effects of Adrenaline.

Classify Oral Antidiabetic Drugs. Write the mechanism of action, uses and adverse effects of Metformin.

a) Define Biotransformation. Describe the consequences of Biotransformation reactions with examples. b) Define Enzyme induction and describe its clinical significance.

Classify Penicillins. Write the mechanism of action, uses and adverse effects of Aminopenicillins. What is the rationale of combining Amoxicillin with clavulanic acid.

Classify Macrolides. Write the mechanism of action, therapeutic uses and adverse effects of Azithromycin.

Classify Antidepressants. Describe the mechanism of action, therapeutic uses and adverse effects of Tricyclic Antidepressants.

Classify NSAIDS. Write the mechanism of action, pharmacological uses and adverse effects of Paracetamol. Add a note on the treatment of paracetamol

Classify the drugs used in Hypertension. Write the mechanism of action, uses and adverse effects of Angiotensin Converting Enzyme (ACE) Inhibitors.

Classify Antiparkinsonian Drugs. Describe the mechanism of action and adverse effects of Levodopa. Enlist the benefits of combining Levodopa with Carbidopa.

Classify the Oral Antidiabetic Drugs. Write the mechanism of action, therapeutic uses and adverse effects of Sitagliptin.

Classify the drugs used in Angina. Write the mechanism of action, therapeutic uses and adverse effects of Nitro-glycerine.

Describe the advantages and disadvantages of Intravenous route of Drug administration.

Therapeutic uses and adverse effects of morphine.

Describe the mechanism of action, therapeutic uses and adverse effects of Selective Estrogen Receptor Modulators (SERMs).

Define apparent Volume of distribution. Describe its clinical significance.

Potassium Channel Openers.

Enlist the drugs used in Hypertensive emergencies with their mechanism of action.

Compare and contrast Succinylcholine and D-Tubocurarine.

Non-sedating Antihistaminics.

Low Molecular Weight Heparins.

Compare and contrast Benzodiazepines and Barbiturates.

Male Contraception.

Name five Immunosuppressant’s. Write their therapeutic uses.

Describe therapeutics uses and adverse effects of Alpha Blockers.

Write a note on how to convince a patient to start insulin as a treatment for his uncontrolled type II Diabetes mellitus.

Enlist atropine substitutes and their Therapeutic uses.

Describe the mechanism of action, therapeutic uses and adverse effects of Thioamides.

Selective Estrogen Receptor Modulators

Classify Anticholinesterases and mention their therapeutic uses.

Centrally acting skeletal muscle relaxants.

Describe the drugs used in the treatment of Cough.

Write various therapeutic uses and adverse effects of Thiazide Diuretics.

Write various therapeutic uses and adverse effects of Potassium Sparing Diuretics.

Explain the mechanisms of action, therapeutic uses and adverse effects of proton Pump Inhibitors.

Halothane.

Describe the mechanism of action and therapeutic uses of Chloroquine.

Explain the mechanism of action, therapeutic uses and adverse effects of Ondansetron.

List out the Regimens used for treating Pulmonary Tuberculosis.

Angiotensin Converting Enzyme Inhibitors.

Describe disease modifying Anti Rheumatoid Drugs.

Treatment of H. Pylori infection.

Methotrexate.

Enlist Prostaglandin Analogues. Describe their Therapeutics uses.

Advantages and disadvantages of Parenteral Iron Preparations.

Albendazole.

Describe how to counsel HIV/ AIDS patient to adhere to Anti-Retroviral Therapy.

Inhaled corticosteroids.

Enlist the drugs used in Psoriasis.

Describe how to motivate patients with coronary artery disease to adhere to the prescribed treatment of the physician.

Mention therapeutic uses and adverse effects of Sulphonamides.

Define Prodrug with two examples.

Teratogenicity.

Outline the Pharmacotherapy of Thyroid Storm.

Define Teratogenicity with two examples.

What are the adverse effects of ACE Inhibitors.

Therapeutic uses of Tetracycline.

Enlist any two uses of Adrenaline with its rationale.

D- pencillamine.

What is Superinfection? Name two group of drugs producing it.

Mention the drugs used in the management of Myasthenia Gravis with its rationale.

Mention three topical Antifungal Agents.

What are the adverse effects of Corticosteroids.

Mention the drugs used in the management of Organo Phosphorous Poisoning with its rationale.

Zero order kinetics.

Mention adverse effects of INH. Explain the rationale of prescribing Pyridoxine with INH (Iso Nicotinic Acid Hydrazide).

Enlist any two Inhalational Corticosteroids used in Bronchial Asthma with their advantages.

Name three drugs used in Psoriasis.

Enlist Dihydrofolate –Reductase Inhibitors.

Mention three different groups of drugs used in Bronchial Asthma with one example for each.

Adverse effects of Levodopa.

Name three Immunosuppressant’s with their therapeutic uses.

Mention three drugs used in generalised Tonic Clonic Seizures.

Mention drugs used in treating Peripheral Arterial Disorders.

What is Malignant Hyperthermia? Mention the drug used for its treatment.

Name three newer anti-epileptic drugs with their mechanism of action.

Mention three drugs used in the treatment of Scabies.

Define Pharmacogenetics. Give two examples.

Enlist Anti Anginal Drugs.

What are the uses of Vitamin C.

Define Tachyphylaxis. Give two examples of drugs causing Tachyphylaxis.

Name three prostaglandin analogues with their indications.

A 20 years old female patient presented with fatigue and shortness of Breath. Her Hb was 7g/dl. Blood smear showed hypochromic Microcytic red cells. How do you treat the above patient?

Mention three advantages of using aluminium Hydroxide and Magnesium Hydroxide as antacid combination.

Enlist three uses and three side effects of Digoxin.

Enlist three vaccines administrated by Intra Muscular Route.

A prodrug is: a) the prototype member of a class of drugs b) the oldest member of a class of drugs c) an inactive drug that is transformed in the body to an active metabolite d) that drug stored in body tissues and released gradually in the circulation

The antiasthma drug which cannot be administered by inhalation route is: a) Theophylline b) Ipratropium bromide c) Budesonide d) Terbutaline

Dissociative anaesthesia' is produced by: a) Ketamine b) Fentanyl c) Propofol d) Both A & B

Which is the most important drug in the treatment of organophosphorus poisoning: a) Atropine sulfate b) Atenolol c) Diazepam d) Adrenaline

Carbamazepine is not used in a) Mania b) Partial seizure c) Trigeminal neuralgia d) Migraine

Among the disease modifying anti-rheumatic drugs, fastest symptom relief is obtained with: a) Auranofin b) Hydroxychloroquine c) Sulfasalazine d) Methotrexate

Drugs having both alpha and beta agonist property a) Propranolol b) Adrenaline c) dopamine d) Diazepam

Which of the following adrenergic agents increases peripheral vascular resistance a) Noradrenaline b) Adrenaline c) Isoprenaline d) None of the above

Which of the following is used as nasal decongestant a) Clonidine b) Dobutamine c) Norepinephrine d) Oxymetazoline

Redistribution is a feature of a) highly lipid soluble drugs b) poorly lipid soluble drugs c) depot preparations d) highly plasma protein bound drugs

If the effect of combination of two drugs is equal to or greater than the sum of their individual effects, the two drugs are exhibiting: a) Tachyphylaxis b) Synergism c) Cross tolerance d) Antagonism

Prolonged lithium therapy can cause: a) Diabetes mellitus b) Goitre c) Parkinsonism d) Gout

The following are the Orphan drugs Except a) Fomepizole b) Acetyl Cysteine c) Erythropoietin d) Flumazenil

Which of the following anticholinergic agents is a CNS depressant a) Atropine b) Scopolamine c) Dicyclomine d) Oxyphenonium

Alpha 1 Blocker without any effect on blood pressure a) Prazosin b) Doxazosin c) Tamsulosin d) Terazosin

All of the following are reversible inhibitors of cyclo-oxygenase except a) Diclofenac b) Aspirin c) Ibuprofen d) Indomethacin

Choose the correct statement below a) Acidic drugs are largely ionized at acid gastric PH b) Basic drugs attain higher concentration extracellularly c) Weakly acidic drugs, ionize more at alkaline PH d) Weakly basic drugs ionize more at alkaline PH

Which of the following drug produce extra pyramidal side effect a) Metoclopramide b) Cisapride c) Domperidone d) All of the above

Directly acting skeletal muscle relaxants is a) Dantrolene sodium b) Pancuronium c) Succinyl choline d) Vecuronium

Classify Sedative Hypnotics. Write in brief the mechanism of action uses, adverse effects of Benzodiazepines

Classify Beta Blockers. Write in brief their uses and adverse effects add a note on Cardio Selective Beta Blockers?

Explain Drug Synergism with examples.

What is the first Pass Metabolism? Explain its significance.

Explain Pharmacogenetics with examples.

Describe the mechanism of action, uses and adverse effects of Carbamazepine.

List commonly used NSAIDs. Explain their mechanism of action and common adverse effects.

Describe the pharmacotherapy of status Asthmatics.

Describe how to motivate patients with long standing hypertension to adhere to the prescribed treatment of the physician.

Explain the rationale of using Tamsulosin in Benign Hypertrophy of Prostate (BHP).

List advantages of second generation Antihistaminics over conventional Antihistaminics.

Name two Mucolytics with indications for their use.

Name two Antimotility Drugs with indications and contraindications.

Explain why Geriatric age group requires special considerations while prescribing medications.

What is Eutectic Mixture of Local Anaesthetics (EMLA)? What is its indication?