KNRUHS MBBS Biochemistry November 2024 (MB2019102 Regular)

MB2019102Kaloji Narayana Rao University of Health Sciences · Biochemistry · 2024 · November · Regular

Questions (25)

1.Name the defective enzyme in maple syrup urine disease (Branched Chain Ketonuria) a) Cystathionine b) Phenyl alanine hydroxylase c) Homogentisic acid oxidase d) Oxidative decarboxylase
1 Mark
2.Increased gastric HCI secretion is found in a) Zollinger- Ellison syndrome b) Gastric carcinoma c) Pernicious anemia d) Gastritis
1 Mark
3.The serum enzyme used to evaluate pancreatic function is a) Acid phosphtase b) Amylase c) Alkaline phosphatase d) Lactate dehydrogenase
1 Mark
4.Which of the following enzymes are involved in Biotransformation? a) Transaminases b) Cytochrome P450 enzymes c) Dehydrogenases d) Decarboxylases
1 Mark
5.Which one of the following enzymes is not a protein, but an RNA molecule a) Amylase b) RNA polymerase c) Urokinase d) Reverse transcriptase
1 Mark
6.An amino acid not found in proteins is a) Homocysteine b) Proline c) Lysine d) Histidine
1 Mark
7.Following are the beneficial effect of Reactive Oxygen Species (ROS), except a) Bactericidal effect b) Reduces blood pressure c) radiotherapy d) Mutations
1 Mark
8.The most abundant protein in mammals is a) Albumin b) Globulins c) Collagen d) Elastin
1 Mark
9.Which of the following is not a biologically important peptide. a) Glutathione b) Angiotensin c) Vasopressin d) leukotriene
1 Mark
10.Which one of the following enzyme acts as biomarker in the diagnosis of prostate cancer a) Amylase b) AST c) Acid phosphatase d) Alkaline phosphatase
1 Mark
11.A 16-year old boy who was given blood transfusion recently had presented with chills and rigors of 2 days duration. Laboratory investigations revealed the following findings: Serum total bilirubin: 4.8 mg/dL, Serum conjugated bilirubin : 0.2 mg/dL, Urine Bilirubin: Negative, Van den Bergh reaction is indirect positive. a) What is the probable diagnosis? b) How do you relate the history and laboratory findings to confirm your diagnosis? (Use flow chart to explain if required) c) Describe normal bilirubin metabolism. d) Name the test performed to identify presence of bile pigments in the urine.
15 Marks
12.Explain the structure of DNA under the following headings: a) Using a neat a labelled diagram explain the structural organization of DNA. b) Name the histone proteins. c) Compare and contrast the differences between DNA and RNA. d) Name the different forms of DNA.
15 Marks
13.Name the different levels of the structural organization or proteins. Discuss the secondary structure of proteins and add a note on the bonds responsible for stabilizing the secondary structure.
6 Marks
14.Write the compounds derived from glycine and their importance
6 Marks
15.Explain how learning influence the Physician Growth.
6 Marks
16.What are tumor markers? Discuss the clinical utility of any three tumor markers.
6 Marks
17.Describe in detail the glomerular function tests. Add a note on the formulae available for calculating estimated glomerular function rate (eGFR).
6 Marks
18.Describe the structure of normal haemoglobin molecule. Add a note on Thalassemia.
6 Marks
19.Explain with diagram the structure of IgG molecule and indicate its binding sites and function of IgG.
6 Marks
20.Name the plasma proteins. Write the functions of serum albumin.
3 Marks
21.Operon Concept.
3 Marks
22.Name the thyroid function tests. Write the reference range for T4 and TSH.
3 Marks
23.Post translational modifications.
3 Marks
24.Phase I detoxification reactions.
3 Marks
25.Alkali reserve.
3 Marks

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