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RGUHS MBBS Biochemistry January 2026 (5506 CBME)

5506Rajiv Gandhi University of Health Sciences · Biochemistry · 2026 · January · CBME

Questions (27)

  1. 1.Describe the metabolic fate and functions of Methionine and Cysteine. Add a note on the diseases associated
    10 Marks
  2. 2.Why Adenosine deaminase deficiency causes lymphocytopenia?
    3 Marks
  3. 3.Justify the statement “When lactose concentration increases, the lac operon is induced”
    3 Marks
  4. 4.Why does Peroxidation of PUFA leads to loss of membrane function?
    3 Marks
  5. 5.Why Urine colour appears pink to red in porphyria cutanea tarda?
    3 Marks
  6. 6.Why do individuals with IgA deficiency often present with recurrent respiratory and gastrointestinal infections?
    3 Marks
  7. 7.A 38-year-old chronic alcoholic male presents with abdominal pain and jaundice. His lab results show, ALT: 150 IU/L, AST: 200 IU/L, ALP: 250 IU/L, GGT: 440 IU/L, Total bilirubin: 8 mg/dl, direct bilirubin: 6 mg/dl. a) What is the probable diagnosis? b) Interpret the laboratory investigation? c) How is bilirubin transported in blood?
    5 Marks
  8. 8.A 58-year-old male with sepsis presents with serum Urea: 120 mg/dl, creatinine: 2.3 mg/dL. urine output: 450 mL/day. a) What is the probable diagnosis? b) Mention the other causes for this organ failure. c) Differentiate creatinine vs urea clearance
    5 Marks
  9. 9.What are the causes for Hypothyroidism? Enumerate thyroid function tests
    5 Marks
  10. 10.Enumerate the applications of Recombinant DNA technology
    5 Marks
  11. 11.Explain the structure of DNA with a neatly labelled diagram
    5 Marks
  12. 12.Define Genetic code. Explain the characteristic features of Genetic code
    5 Marks
  13. 13.Explain structural and functional relationship of proteins
    5 Marks
  14. 14.What are Acute phase proteins? Give examples and mention their clinical significance
    5 Marks
  15. 15.Define Xenobiotics. Explain the phases of detoxification
    5 Marks
  16. 16.Explain the pathway of Uric acid synthesis
    5 Marks
  17. 17.Identify and discuss the physician’s role and responsibility to society that he/she serves
    5 Marks
  18. 18.A 1-year-old female infant was brought to the OPD with complaints of weakness, lethargy and decreased growth. On examination she was anemic, and urine contained elevated levels of orotic acid
    (i) Administration of which of the following alleviates the symptoms? A. Adenine B. Guanine C. Thymidine D. Uridine
    (ii) which laboratory test differentiates deficiency of uridine monophosphate synthase from ornithine transcarbamoylase deficiency A. Blood ammonia B. Serum creatinine C. Uric acid D. Electrolytes
    2 Marks
  19. 19.A 10-year-old girl is brought by her parents to the family doctor. She has many freckles on her face, neck arms and hands. Parents reported she is unusually sensitive to sunlight. Two basal cell carcinomas are also identified on her face.
    (i) What is the probable diagnosis? A. Hereditary nonpolyposis colon cancer B. Xeroderma pigmentosum C. Ataxia tielangiectasia D. Riboflavin deficiency
    (ii) Which of the following is likely to be defective in this patient? A. Repair of double strand breaks by error prone homologous recombination B. Removal of mismatched bases from 3’end by methyl directed process. C. Removal of pyrimidine dimers from DNA by nucleotide excision repair D. Removal of Uracil from DNA by base excision repair
    2 Marks
  20. 20.A 2-week-old infant is diagnosed with an urea cycle defect. Enzymatic analysis showed no activity for Ornithine transcarbamoylase. Molecular analysis revealed that the mRNA product of the gene for OTC was identical to that of a control
    (i) Which of the techniques was most likely used to analyse mRNA? A. Northern Blot B. Western Blot C. Southern Blot D. Eastern blot
    (ii) Which phase of Central dogma was affected in this patient? A. Replication B. Transcription C. Translation D. None of the above
    2 Marks
  21. 21.A 40-year old female presented to the clinic with lump in right breast. A mammogram performed revealed a breast mass with numerous macrocalcifications suggestive of breast cancer.
    (i) What cancer gene might be associated? A. BRCA gene B. P53 C. FAP D. RB
    (ii) What is the tumour marker associated with breast cancer? A. PSA B. CA-125 C. AFP D. HER-2 neu
    2 Marks
  22. 22.A 50-year-old man presented with painful blisters on the backs of his hands. He was a golf instructor and indicated that the blisters had erupted shortly after the golfing season began.The patient’s urine was reddish orange. A 24-hour urine collection showed elevated uroporphyrin
    (i) The most likely diagnosis is: A. Congenital erythropoietic porphyria B. Acute intermittent porphyria. C. Hereditary coproporphyria. D. Porphyria cutanea tarda
    (ii) The enzyme deficient in this porphyria is A. UPG III co Synthase B. UPG decarboxylase C. CPG III Oxidase D. PBG deaminase
    2 Marks
  23. 23.An adolescent girl presents with subluxation of lens and mental retardation. On examination she is tall and thin with elongated limbs. Mild scoliosis was present with pectus excavatum and genu valgum. One of her sisters had similar complaints.
    (ii) What is the enzyme deficient in this disorder? A. Cystathionine Beta Synthase B. Cystathionase C. Methionine Adenosyl transferase D. None of the above
    1 Mark
  24. 24.A 32-year old woman presented to surgery OPD with complaints of pain abdomen with irregular menstrual cycles. She also had history of sudden weight loss. Ultrasound abdomen shows mass in the ovaries. She was diagnosed to have carcinoma of ovaries.
    (i) Cancer is mainly caused by A. Uncontrolled meiosis B. Uncontrolled mitosis. C. Cell rupture D. Loss of immunity
    (ii) Cancer causing oncogenes are not expressed because of the presence of A. Protooncogenes B. Tumor promoters C. Tumour suppressor genes D. Jumping genes
    2 Marks
  25. 25.A first year MBBS student after her biochemistry free radicals lecture class decided to include Aqueous phase antioxidant in her daily diet.
    (i) The antioxidant is A. Vitamin E B. Vitamin A C. Vitamin D D. Vitamin C
    (ii) Chain breaking Anti-oxidant is A. Vitamin E B. Vitamin A C. Vitamin D D. Vitamin C
    2 Marks
  26. 26.A 55-year old female presented to dermatology OPD with complaints of swelling of lips, rashes all over the body and facial puffiness. She gives history of having food from outside the previous night. She was diagnosed to have Urticaria. She was advised for serum investigations. 26 26
    (i) Which of the following Immunoglobulins will be elevated A. IgA QP CODE : 5506 B. IgM C. IgE D. IgG
    (ii) One of following is true about the elevated Immunoglobulin in the above condition A. Contributes to 75-80% of total Ig B. Macroglobulins C. Secretory antibodies. D. Have the property to fix on mast cells
    2 Marks
  27. 27.A person came with a complaint of wrong results of his blood sugar level. The technologist approached consultant biochemist for the same.
    (i) What did the biochemist check EXCEPT? A. Daily Internal QC B. Values of blood sugar in the analyser C. LJ chart D. External Quality control
    (ii) The sample for blood sugar analysis should be collected in A. EDTA vacutainer B. Heparin vacutainer C. Sodium fluoride vacutainer D. Citrate vacutainer
    2 Marks

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