KNRUHS MBBS Biochemistry November 2025 (MB2019102 Regular)

MB2019102Kaloji Narayana Rao University of Health Sciences · Biochemistry · 2025 · November · Regular

Questions (25)

1.One of the following vitamins is associated with purine synthesis a) Folate b) Biotin c) Pyridoxine d) Vitamin B12
1 Mark
2.Vanden Bergh reaction is indirect positive in which jaundice a) Hepatocellular b) Hemolytic c) Obstructive d) All of the above
1 Mark
3.Following are the tests used to assess the gastric function except a) Pentagastrin stimulation test b) Alcohol test meal c) Urea clearance d) Insulin test meal
1 Mark
4.All of the following porphyrias are inherited as autosomal dominant, except a) Porphyria cutana tarda b) Congenital erythropoietic porphyria c) Protoporphyria d) Acute intermittent porphyria
1 Mark
5.The substance that facilitates the release of oxygen from oxyhemoglobin to the tissues a) H+ ion b) CI-- ions c) 2,3 —Bisphospho glycerate d) Glucose
1 Mark
6.Endocrine gland that is associated with the regulation of BMR a) Pituitary b) Thyroid c) Adrenal d) Endocrine part of pancreas
1 Mark
7.Which one of the following is a cancer suppressor gene a) sis b) ras c) erb-B d) p53
1 Mark
8.The factories of protein biosynthesis is a) Nucleus b) Ribosomes c) Mitochondrion d) Cell sap
1 Mark
9.Regan isoenzyme is increased in a) Lung cancer b) Osteoporosis c) Paget's disease d) Myocardial infarction
1 Mark
10.The principal cation in intracellular fluid is a) Sodium b) Potassium c) Calcium d) Magnesium
1 Mark
11.A 6-month-old infant began to vomit occasionally and ceased to gain weight at 9 months of the age. He was readmitted to the hospital. After one week he became drowsy had fever, pulse was elevated and there was hepatomegaly. EEG was done and was grossly abnormal. Blood ammonia was elevated and urine contained high amount of glutamine and uracil a) What is probable diagnosis? b) What is pathogenic mechanism involved? c) Describe how ammonia of aminoacid is metabolised? d) What is the normal plasma concentration of ammonia?
15 Marks
12.What are the types of DNA repair and name the diseases caused by various mutations.
15 Marks
13.Structural organization levels of Proteins.
6 Marks
14.Mention the different types of tumour markers. Describe the significance of any three tumour markers.
6 Marks
15.Salvage pathway of Purine synthesis and add a note on Lesch Nyhan syndrome.
6 Marks
16.Discuss the Renal mechanisms involved in regulation of blood pH.
6 Marks
17.Define detoxification. Write in detail on the phases of detoxification and mention examples clinically related where ever necessary.
6 Marks
18.Degradation of Haemoglobin.
6 Marks
19.Explain the commitment to lifelong learning is related to physician growth.
6 Marks
20.Synthetic Nucleotides.
3 Marks
21.Autoimmunity.
3 Marks
22.Hartnup`s disease.
3 Marks
23.Calculate the anion gap using the following data: serum Sodium: 145 mmol/L, Serum potassium; 4.0mmol/L, Serum bicarbonate – 24mmol/L, serum chloride: 104 mmol/L.
3 Marks
24.Genetic code.
3 Marks
25.Explain Chloride shift.
3 Marks

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