apyqace

RGUHS MBBS Biochemistry January 2026 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2026 · January · CBME

Questions (30)

  1. 1.A 60-year-old female presents to the emergency department with acute onset shortness of breath. Symptoms began approximately 2 days before and had progressively worsened with no associated, aggravating, or relieving factors. Past history revealed she had similar symptoms approximately 1 year ago with an acute, chronic obstructive pulmonary disease (COPD) exacerbation requiring hospitalization. Her arterial blood gas analysis report revealed the following: pH 7.25, PCO2 68, PO2 48 and HCO3- 24 mmol/L. a) What is the acid-base disturbance of the above patient? b) Mention the normal pH of blood. c) Explain the role respiratory mechanism in maintenance of acid-base balance. d) List two other clinical conditions causing such acid-base disturbance.
    10 Marks
  2. 2.List the types of enzyme inhibition. Differentiate competitive and noncompetitive inhibition with examples. Describe allosteric regulation of enzyme.
    10 Marks
  3. 3.A 47-year-old female came with the complaints of fatigue and bilateral tingling & numbness in her extremities. The symptoms were progressive and was gradually getting worse. Dietary history revealed she was on vegan diet. Neurological examination revealed numbness in all extremities with decreased vibration senses. Provisional diagnosis of Vitamin B12 deficiency was made. a) Mention the RDA and dietary sources of Vitamin B12. b) Enumerate the biochemical functions of Vitamin B12. c) Explain ‘folate trap’.
    5 Marks
  4. 4.A 9-year-old girl presented to Pediatric OPD with frequent experience of muscle pain and cramps. She also complained of weakness in hands and feet. Diet history revealed she was aversion towards milk or milk products. On examination, Trosseau’s and Chovstek’s signs were positive. a) Name the mineral associated with above condition. b) List the hormones involved in regulating the above mineral and explain how it is regulated. c) Mention the reference range of above mineral in serum.
    5 Marks
  5. 5.“Gluconeogenesis is not a simple reversal of glycolysis” – Justify it by stating the reactions catalysed by key enzymes of gluconeogenesis.
    5 Marks
  6. 6.Name the ketone bodies. Write the pathway for ketogenesis. Mention two clinical conditions associated with ketonuria.
    5 Marks
  7. 7.Define basal metabolic rate (BMR). Mention the factors affecting BMR.
    5 Marks
  8. 8.Mention the types of diabetes mellitus. Describe the metabolic changes in diabetes mellitus. List two microvascular complications associated with diabetes mellitus.
    5 Marks
  9. 9.Mention the dietary sources, RDA and biochemical functions of Vitamin E.
    5 Marks
  10. 10.Define glycogenolysis. Write the reactions of glycogenolysis. State two glycogen storage disorders mentioning the enzyme defect.
    5 Marks
  11. 11.Write the functions of: a) Rough endoplasmic reticulum b) Mitochondria c) Lysosomes
    3 Marks
  12. 12.State the biochemical defect and clinical features associated with a) Osteogenesis imperfecta b) Ehler Danlos Syndrome
    3 Marks
  13. 13.Define oligosaccharide. Give two examples of oligosaccharide. Mention their biomedical importance.
    3 Marks
  14. 14.What are trans-fatty acids and state their adverse effect?
    3 Marks
  15. 15.What are apolipoproteins? List two apolipoproteins and mention their significance.
    3 Marks
  16. 16.Mention one inhibitors for the following complexes in electron transport chain: a) Complex I b) Complex II c) Complex IV
    3 Marks
  17. 17.List two enzymes in which copper is a cofactor. Write the clinical features of the disorder associated with copper excess.
    3 Marks
  18. 18.Define balanced diet. Write the composition of balanced diet.
    3 Marks
  19. 19.Define hyponatremia. Mention two clinical conditions associated with hyponatremia.
    3 Marks
  20. 20.Name the precursor molecule in the synthesis of prostaglandins. Mention four clinical significance of prostaglandins.
    3 Marks
  21. 21.Which vitamin availability reduces the requirement of selenium? A. Vitamin A B. Vitamin D C. Vitamin E D. Vitamin K
    1 Mark
  22. 22.Membrane fluidity is determined by A. Nature of fatty acids B. Glycosylation of integral proteins C. Membrane pumps D. Distribution of peripheral proteins
    1 Mark
  23. 23.Amphipathic lipids forming spherical vesicles consisting of one or more phospholipid bilayers is A. Micelle B. Liposome C. Emulsion D. Biomembrane
    1 Mark
  24. 24.Which of the following food have high glycemic index? A. Potato chips B. Ice-cream C. Legumes D. Milk
    1 Mark
  25. 25.An example for physiological uncoupler is A. 2,4 dinitophenol B. 2,4 dinitrocresol C. Chlorocarbonylcyanide phenylhydrazone D. Thermogenin
    1 Mark
  26. 26.Swollen and spongy gums, and poor wound healing are the symptoms associated with deficiency of A. Ascorbic acid B. Thiamine C. Niacin D. Biotin
    1 Mark
  27. 27.Hyaluronic acid is seen in A. Synovial fluid B. Cartilage C. Cornea D. Bones
    1 Mark
  28. 28.All of the following causes hyponatremia EXCEPT A. Cushing’s disease B. Addison’s disease C. Renal tubular acidosis D. Angiotensin Converting Enzyme (ACE) inhibitors
    1 Mark
  29. 29.Diagnostic enzyme for acute pancreatitis is A. Creatine Kinase - MB B. Acid phosphatase C. Aldolase D. Lipase
    1 Mark
  30. 30.Hexose Monophosphate (HMP) Shunt pathway is necessary for all the following EXCEPT A. Transparency of lens B. RBC membrane integrity C. Reduce methemoglobin level D. Production of 2,3-Bisphosphoglycerate (BPG) for erythrocytes
    1 Mark

More from Biochemistry

Biochemistry question papers & analysis

Previous-year question paper.More papers →Report an issue
Question content is not available for printing. View it at pyqace.com