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RGUHS MBBS Biochemistry January 2026 (5505 CBME)

5505Rajiv Gandhi University of Health Sciences · Biochemistry · 2026 · January · CBME

Questions (27)

  1. 1.Describe the steps of Beta-Oxidation of Palmitic acid with energetics. Add a note on its regulation
    10 Marks
  2. 2.Kussmaul’s Breathing is seen in Metabolic acidosis. Justify.
    3 Marks
  3. 3.a. Premature babies with low L/S ratio are known to develop respiratory distress syndrome. Justify b. Lysosomes are called Suicidal bags. Give reason
    3 Marks
  4. 4.Vitamin B12 is always used with Folic acid in treatment of Macrocytic anaemia - Give reasons.
    3 Marks
  5. 5.Sodium glucose transport is called secondary active transport. Justify.
    3 Marks
  6. 6.Dietary fibres are included in balanced diet. Give reasons.
    3 Marks
  7. 7.Enumerate the biomarkers used in diagnosis of Myocardial infarction. Discuss the pattern of elevation of various enzymes in Myocardial infarction
    5 Marks
  8. 8.Discuss the Nutritional Causes of Anaemia. Add a note on Absorption, Transport and storage of Iron
    5 Marks
  9. 9.A patient comes to physician’s clinic with chief complaints of swelling of gums, petechial hemorrhages with easy bruisability since 3 months a) What is the deficient water soluble vitamin? b) Explain the biochemical functions of deficient vitamin. c) Describe the deficiency manifestations of the vitamin
    5 Marks
  10. 10.Discuss the biochemical and clinical significance of HMP shunt pathway.
    5 Marks
  11. 11.Compare and contrast between competitive and non-competitive enzyme inhibition with suitable examples.
    5 Marks
  12. 12.Describe Oxidative phosphorylation. Add a note on its inhibitors
    5 Marks
  13. 13.Explain different types of protein-energy malnutrition.
    5 Marks
  14. 14.What are homopolysaccharides? Give examples. Explain their importance
    5 Marks
  15. 15.Explain the respiratory regulation for Acid-Base balance.
    5 Marks
  16. 16.What are poly unsaturated fatty acids? Give examples. Mention their significance
    5 Marks
  17. 17.Enumerate the advantages of Physician being a Life-long learner.
    5 Marks
  18. 18.An adult lady came to OPD with complaints of fever and abdominal pain (right hypochondrial region) since 3 days. Patients gives history of passing high colored urine with normal color of stools. On examination, yellowish discoloration of skin and sclera are noticed.
    (i) All the following enzyme levels will help in the diagnosis of above case EXCEPT A. Alanine Transaminase B. Aspartate Transaminase C. Acid Phosphatase D. Alkaline Phosphatase
    (ii) Which the following enzymes is likely to be increased significantly in the above case? A. Alanine Transaminase B. Acid Phosphatase C. Alkaline Phosphatase D. Amylase
    2 Marks
  19. 19.A 25-year-old went for trekking and he developed headache, dizziness, breathing difficulty sometime after reaching the peak. ABG data is as follows. Blood pH – 7.54, pCO2 – 20 mm Hg, plasma bicarbonate– 26 mEq/L
    (i) What is the Acid -base disorder in the above case? A. Metabolic Acidosis B. Metabolic alkalosis C. Respiratory Acidosis D. Respiratory Alkalosis
    (ii) What is the compensatory Mechanism? A. Hyperventilation B. Hypoventilation C. Reabsorption of bicarbonate ion D. Excretion of bicarbonate ion
    2 Marks
  20. 20.A 16-year-old lady came with history of imbalance while walking, weakness in both lower limbs since 5 months. She has difficulty in combing hair and buttoning clothes. On examination, she had ataxic gait.
    (i) What is the deficient vitamin in the above case? A. Vitamin A B. Vitamin B1 C. Vitamin B6 D. Vitamin C
    (ii) The biochemical function of the deficient vitamin in the above case is: A. Acetylation B. Gamma carboxylation C. Oxidative decarboxylation D. Transamination
    2 Marks
  21. 21.A 5-year-old boy residing at kolar came to dentist with complaints of yellowish discoloration of teeth. On examination dentist observed mottling and stratification of teeth.
    (i) Abnormality of which of the following nutrient causes the above condition? A. Calcium B. Copper C. Iodine D. Fluorine
    (ii) The biochemical function of the abnormal nutrient is: A. Protects Gums B. Formation of teeth C. Protects enamel D. Mineralization of teeth
    2 Marks
  22. 22.7-month-old child was brought to the OPD with failure to thrive and bilateral opacities in the eye. On examination the child was found to have bilateral cataract, hepatomegaly and mental retardation
    (i) What is the probable diagnosis for the above case? A. Galactosemia B. Pompe’s disease C. Niemann-pick disease D. Von-Gierke’s disease
    (ii) Which is the enzyme deficient in the above condition? A. Galactose-1-phosphate pyrophosphorylase B. Galactose-1-phosphate uridyl transferase C. Glucose-6-phosphatase D. Liver phosphorylase
    2 Marks
  23. 23.A 40-year-old person came with complaints of weight loss inspite of repeated eating, increased frequency of urination and recurrent infections. Provisional diagnosis of Diabetes mellitus is made.
    (i) What is the diagnostic criteria for Diabetes mellitus? A. FBS >100 mg/dL B. PPBS >200 mg/dL C. HbA1c >5.4 % D. All of the above
    (ii) Which of these investigations is not used for monitoring of Diabetes mellitus patient? A. FBS B. PPBS C. HbA1c D. OGTT
    2 Marks
  24. 24.A 14-year-old boy came with complaints of generalized weakness, epileptic seizures and abdominal pain. On examination was found to have hepatomegaly and Kayser Fleischer ring around cornea.
    (i) What is the biochemical defect? A. Decreased copper in diet B. Decreased absorption of copper C. Decreased copper binding protein D. Increased excretion of copper
    (ii) The penicillamine used in the treatment acts by A. Increasing absorption of copper B. Increasing binding of copper C. Increasing transport of copper D. Increasing excretion of copper
    2 Marks
  25. 25.A 7-month-old child fell while crawling and presented with swollen leg. X-ray of affected leg showed fracture of femur. The bones were found to be thin. Past history revealed that by then child has had multiple fractures.
    (i) What is the disorder of extracellular matrix in the above case? A. Ehlers-Danlos syndrome B. Marfans syndrome C. Osteogenesis imperfecta D. Menkes disease
    (ii) The condition is caused is due to defect in ______________ A. Collagen type I B. Collagen type III C. Elastin type II D. Fibrillin Type I
    2 Marks
  26. 26.A young boy met with a road traffic accident and lost the lot of blood due to injury. Renin angiotensin system plays a major role in the maintenance of fluid balance.
    (i) All the following Factors stimulate the renin release EXCEPT: A. Angiotensin II B. Decreased blood pressure C. Salt depletion D. Prostaglandins
    (ii) Which of the following is the action of Angiotensin converting enzyme (ACE)? A. Converts angiotensinogen to angiotensin I B. Converts angiotensin I to angiotensin II C. Converts angiotensin II to angiotensin III D. Converts angiotensin III to angiotensin II
    2 Marks
  27. 27.A 8 month old girl was brought to the clinic in an irritable state. Weight was much lower than expected, mid arm circumference was low for age. The mother had stopped breast feeding at the age of 5 months and was now giving diluted formula milk. There was no evidence of swelling or abdominal distension.
    (i) Which of the following is true for the above nutritional disorder? A. Essential fatty acid deficiency B. Primary protein deficiency C. Primary calorie deficiency D. Both calorie and protein deficiency
    (ii) Which of the following is the biochemical laboratory finding will be observed in above nutritional disorder? A. Normal serum albumin and increased serum cortisol levels B. Increased serum albumin and serum cortisol levels C. Decreased both serum albumin and serum cortisol levels D. Increased serum albumin and normal serum cortisol levels
    2 Marks

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