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KUHS MBBS Biochemistry Previous Question Paper - February 2022 (116001 2019 Scheme)

116001Kerala University of Health Sciences · Biochemistry · 2022 · February · 2019 Scheme

Questions (22)

  1. 1.A 70-year-old male presented to his family physician with yellow discoloration of sclera associated with epigastric pain and weight loss. Urine had become darker in color and his stools pale. A CT scan of the abdomen revealed a tumor in the pancreas. Investigations: Total Bilibrubin–4.2mg/dl; Direct Bilirubin–3.8mg/dl; ALP–510U/L; AST–80U/L; ALT-76U/L. Answer the following using the above data: • What is the probable diagnosis • Define and classify Jaundice • Which enzyme is specific for this type of jaundice and why • Explain the urinary findings • Why urine is dark in color and stools pale • Enumerate the causes of jaundice • List the laboratory investigations used to differentiate between the types of jaundice.
    15 Marks
  2. 2.Describe the process of transcription by providing the details on the following • Requisites • Promoters • Pre – initiation complex • Initiation, Elongation and termination • Inhibitors • Post – transcriptional modifications
    15 Marks
  3. 3.What is the normal reference range for serum calcium. How is it regulated.
    8 Marks
  4. 4.Define metabolic alkalosis. What are the characteristic features and causes of metabolic alkalosis. Mention the compensatory mechanisms.
    8 Marks
  5. 5.Describe the various stages of replication and add a note on DNA repair mechanism
    8 Marks
  6. 6.Primary and secondary immune response
    8 Marks
  7. 7.What are the sources for purine ring. Enumerate the reactions in denovo synthesis of purine nucleotide. Add a note on its regulation.
    8 Marks
  8. 8.Collagen
    4 Marks
  9. 9.Antioxidants
    4 Marks
  10. 10.Give two examples for Phase II detoxification reaction.
    4 Marks
  11. 11. C peptide
    4 Marks
  12. 12.Structure of tRNA and its function
    4 Marks
  13. 13.Reference level of S. creatinine and blood urea.
    1 Mark
  14. 14.Mention any two applications of Electrophoresis
    1 Mark
  15. 15.Two tumour suppressor genes.
    1 Mark
  16. 16.Mention any two post translational modifications
    1 Mark
  17. 17.Name any two Iron containing enzymes
    1 Mark
  18. 18.Give the principle of RIA
    1 Mark
  19. 19.Give the normal albumin : globulin ratio
    1 Mark
  20. 20.Wobble effect
    1 Mark
  21. 21.Two enzymes as tumor markers and their clinical relavance
    1 Mark
  22. 22.Give the names of compounds used for estimating clearance
    1 Mark

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