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KUHS MBBS Biochemistry Previous Question Paper - November 2023 (116001 2019 Scheme)

116001Kerala University of Health Sciences · Biochemistry · 2023 · November · 2019 Scheme

Questions (22)

  1. 1.A 54-year-old man was admitted to emergency in a disoriented state. He had a feeble pulse, low blood pressure and sweetish odour of breath. Arterial blood gas analysis showed pH : 7.1, HCO3 :11 mmol/L, pCO2 : 38 mmHg. a) What is the most likely acid base disorder in this case b) Interpret the ABG findings and give the normal reference interval c) Give four causes for the above acid base disorder d) Enumerate the major buffer systems in the body e) Discuss the renal regulatory mechanisms of acid base balance
    15 Marks
  2. 2.Describe the absorption, transport and storage of iron in the body. Explain the regulation of iron homeostasis. Enumerate the biochemical functions of iron. Add a note on disorders associated iron metabolism.
    15 Marks
  3. 3.Give the sources of carbon and nitrogen atoms of purine and pyrimidine rings. How is the de novo synthesis regulated. Indicate the clinical uses of inhibitors of purine nucleotide synthesis.
    8 Marks
  4. 4.Describe the process of DNA replication in eukaryotes. Name two inhibitors of replication.
    8 Marks
  5. 5.Describe recombinant DNA technology. Add a note on its applications.
    8 Marks
  6. 6.Name the renal clearance tests. Give details of any one of them. What is its clinical significance
    8 Marks
  7. 7.Enumerate the immunoglobulin and classify their functions. Describe the structure of immunoglobulins.
    8 Marks
  8. 8.Oncogenes
    4 Marks
  9. 9.Hormonal regulation of calcium level
    4 Marks
  10. 10.Van den Bergh test
    4 Marks
  11. 11.Post translational modifications.
    4 Marks
  12. 12.Antioxidants
    4 Marks
  13. 13.Hyperkalaemia is treated by giving glucose and insulin. Why
    1 Mark
  14. 14.Name two antimutagens
    1 Mark
  15. 15.Enlist two applications of Southern blotting technique.
    1 Mark
  16. 16.Name two vectors used for gene therapy.
    1 Mark
  17. 17.What is apoptosis.
    1 Mark
  18. 18.Name two inhibitors of RNA synthesis
    1 Mark
  19. 19.Enzyme defect in orotic aciduria.
    1 Mark
  20. 20.Name two copper containing enzymes.
    1 Mark
  21. 21.Which amino acids are used for detoxification.
    1 Mark
  22. 22.Give the reference interval in plasma to (a) Sodium (b) Chloride
    1 Mark

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