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KUHS MBBS Biochemistry Previous Question Paper - January 2024 (116001 2019 Scheme)

116001Kerala University of Health Sciences · Biochemistry · 2024 · January · 2019 Scheme

Questions (22)

  1. 1.A 68-year-old man, known diabetic for the past 20 years was brought to the emergency in a disoriented state. Relatives informed that he had fever for the last few days and skipped his regular doses of insulin. On examination he had rapid pulse and rapid deep breathing. Laboratory results as follows: pH: 7.2, HCO3-: 12 meq/L, PCO2:35mm of Hg, Na+:135meq/L, K+:4.9meq/L,Cl-: 101meq/L a) What is the most likely acid base disorder in this patient b) Calculate anion gap and comments c) Interpret the given laboratory parametres and give their reference interval d) Enumerate the causes for this type of acid base imbalance e) Describe the role of lungs and kidney in maintaining normal plasma pH
    15 Marks
  2. 2.Give a detailed account of the transcription process. How is it regulated. Name inhibitors of transcription
    15 Marks
  3. 3.What is Gout. Give an account of the causes, biochemical base of clinical manifestations, investigations and management of Gout
    8 Marks
  4. 4.Describe the principles and applications of ELISA
    8 Marks
  5. 5.Enumerate liver function tests. Describe any two of them in detail
    8 Marks
  6. 6.Describe recombinant DNA technology. What are the applications of the technique
    8 Marks
  7. 7.Explain the salient features of structural organization of collagen. Mention the major disorders associated with collagen structure and function
    8 Marks
  8. 8.What is code. Describe the salient features of genetic code
    4 Marks
  9. 9.Biochemical test for the investigation of iron deficiency anaemia
    4 Marks
  10. 10.Biochemical functions of Copper and disorders associated with copper metabolism
    4 Marks
  11. 11.Reactive oxygen species
    4 Marks
  12. 12.Detoxification of bilirubin
    4 Marks
  13. 13.What is genetic code.
    1 Mark
  14. 14.Action of reverse transcriptase
    1 Mark
  15. 15.Normal serum values of sodium and potassium
    1 Mark
  16. 16.References interval for the plasma electrolytes a) sodium b) Potassium
    1 Mark
  17. 17.Define mutation
    1 Mark
  18. 18.Enzyme defect in orotic aciduria
    1 Mark
  19. 19.Name two tumor markers and their clinical applications
    1 Mark
  20. 20.Define apoptosis
    1 Mark
  21. 21.Name types of immune responses
    1 Mark
  22. 22.Mention two causes of metabolic alkalosis
    1 Mark

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