KUHS MBBS Biochemistry Previous Question Paper - July 2024 (116001 2019 Scheme)

116001Kerala University of Health Sciences · Biochemistry · 2024 · July · 2019 Scheme

Questions (18)

1.Single response type questions
Transparency of corneal endothelium is maintained by a) Heparan sulphate b) Chondroitin sulphate c) Keratan sulphate d) Hyaluronic acid
All the following are nucleic acids, EXCEPT a) Plasmids b) Prions c) Cosmids d) Virions
All the following statements about a live attenuated vaccine are true, EXCEPT a) A single dose is sufficient b) It induces shorter but effective immunity c) It induces humoral and cell-mediated immunity d) It can be administered by the route of natural infection to induce local immunity
Mismatch repair defect is seen in a) Xeroderma pigmentosa c) MutyH Polyposis b) Hereditary Non polyposis colorectal cancer d) Ataxia Telangiectasia
Which of the following is NOT an emergency investigation a) Potassium b) Fasting glucose c) Creatinine d) Calcium
5 Marks
2.Multiple response type questions. Read the statements and mark the answers appropriately
Regarding gene therapy choose the correct statement 1) In ex-vivo strategy, patients’ cells with modified genes are administered to the patient 2) In in-situ strategy, expression cassette is introduced to the patients’ blood or tissue 3) In in-vivo strategy, vector is administered to the cells or tissues 4) Somatic gene therapy is being tried a) 1 & 2 b) 1, 2 & 3 c) 1, 3 & 4 d) All are correct
Choose the correct statement about plasmids 1) They are circular single-stranded RNA 2) Replicate independent of bacterial DNA replication 3) Specialised regions of bacterial chromosomes 4) Confer antibiotic resistance to host bacteria a) 1 & 2 b) 1, 3 & 4 c) 2 & 4 d) 2, 3 & 4
From pairs of diseases and associated abnormalities, pick out the mismatched pair: 1) Maple syrup urine disease and metabolic acidosis 2) Conn’s syndrome and Metabolic acidosis 3) SIADH (Syndrome of Inappropriate Antidiuretic Hormone) and hypertonic expansion 4) Waldenstrom’s macroglobulinemia and hyperviscosity a) 2 & 4 b) 1, 2 & 3 c) 1 & 3 d) 2 & 3
Which of the following diseases are not attributed to free radical injury 1) Hypothyroidism 2) Cataract 3) Reperfusion injury 4) Type II Diabetes Mellitus a) 1 & 2 b) 1 & 4 c) 2 & 4 d) 2 & 3
The laboratory data that is against a diagnosis of obstructive jaundice is 1) High alkaline phosphatase level 2) Increased excretion of urobilinogen in urine 3) Elevated serum cholesterol level 4) Indirect positive van den Bergh reaction a) 2 & 4 b) 2 & 3 c) 3 & 4 d) 1, 2 & 4
5 Marks
3.There are two statements marked as-Assertion (A) and Reason (R). Mark your answer as per the options provided
Assertion(A): Analysis of plasma glucose in a plain tube can be done at any time after collecting sample – there won’t be any change in plasma glucose level. Reason(R): Glycolysis will reduce the patient blood glucose level a) Both A and R are correct c) Both A and R are incorrect b) A incorrect R correct d) A correct R incorrect
Assertion(A): Cytochrome P450 is the chief enzyme responsible for clearance of majority of drugs Reason(R): Cytochrome P450 catalyses through conjugation a) Both A and R are correct but R is not the reason for A c) Both A and R are incorrect b) A correct R incorrect d) Both A and R are correct R is the reason for A
Assertion(A): Restriction fragment length polymorphism can be used to settle cases of disputed parenthood Reason (R): Both chromosomes of a pair show similar restriction pattern a) Both A and R are correct c) Both A and R are incorrect b) A incorrect R correct d) A correct R incorrect
Assertion(A): In hepatic jaundice, Hay’s test will be positive Reason (R): Hay’s test is used to detect conjugated bilirubin a) Both A and R are correct R is the reason for A c) Both A and R are incorrect b) A correct R incorrect d) Both A and R are correct R is not the reason for A
Assertion (A): Creatinine clearance is a better index than urea clearance Reason (R): Creatinine clearance is not affected by dietary protein Consumption a) Both A and R are correct but R is not the reason for A c) Both A and R are incorrect b) A incorrect R correct d) Both A and R are correct, R is the reason for A
5 Marks
4.A 15-year old African boy studying in India was admitted to the medical ward with complaints of fever and severe body pains. On examination, hepatosplenomegaly was detected. His Hb levels were found to be very low (6.5g/dL).Microscopic examination of his blood smear revealed sickle-shaped RBC
Molecular basis of HbS is a) Normal 2α and 2β globin chains c) Normal 2α and abnormal 2β globin chains b) Abnormal 2α and normal 2β globin chains d) Abnormal 2α and 2β globin chains
All the below complications can occur for the boy EXCEPT a) Vasoocclusive crisis b) Organ damage c) Bleeding disease d) Pain and swelling in joints
In HbS, which of the following is true. a) Valine replaced by glutamate c) Glutamate replaced by valine b) Valine replaced by glycine d) Glycine replaced by valine
In sickle cell disease, sickling of RBCs is favorable when hemoglobin S is in a) Oxygenated form b) Deoxygenated form c) Glycated form d) Oxidized form
Regarding HbS and HbA all are true EXCEPT a) Inclusion bodies will be seen both in HbS and HbA b) Solubility of deoxy HbS is lower than deoxy HbA c) HbS is slower moving on electrophoresis than HbA d) Structural difference is with regard to beta chain
5 Marks
5.An unconscious patient was rushed to the Emergency department of the hospital. History taken from the attendant revealed that patient was a known Diabetic, blood samples were collected and sent to clinical laboratory for analysis. a) What could be your probable diagnosis b) Which relevant investigations you would suggest for this patient c) Explain the role of Kidneys in maintenance of Acid base homeostasis d) How is the compensation brought about in this patient
10 Marks
6.Define and explain the steps involved in the process of Translation. What is Post Translational modifications, give four examples
10 Marks
7.A patient gave history of recurrent episodes of vomiting and fever. On examination he was icteric, dehydrated and his liver was palpable. Following is the biochemical report of this patient: Serum total Bilirubin- 12 mg% conjugated bilirubin – 5.5 mg %, unconjugated bilirubin - 6.5 mg %, serum Alkaline phosphatase – 278 IU /L, AST – 235 IU/L , ALT – 365 IU/ L, Bile salts – Negative, Bile Pigments – positive , Fecal stercobilinogen – positive. a) What could be your probable Diagnosis b) Explain how Bilirubin is formed and excreted from the body.
6 Marks
8.Discuss the clinical features, Biochemical basis and diagnosis of Gout
6 Marks
9.Thyroid function tests and their significance
6 Marks
10.Polymerase chain Reaction
6 Marks
11.Differentiate between active and passive immunity
6 Marks
12.Glucose Tolerance Test – give two indications. Explain the different responses seen
6 Marks
13.Role of Glucuronic acid in Detoxification
4 Marks
14.Chain breaking and Preventive antioxidants
4 Marks
15.Structure and two functions of Collagen
4 Marks
16.Give reason: a) Plasmids are used commonly as vectors in recombinant DNA techniques b) Low salt diet is recommended in patients with hypertension
4 Marks
17.Explain the Biochemical basis of : a) Folate antagonists are used as anti cancer drugs b) Hyperkalemia is a life threatening situation
4 Marks
18.Doctors should have a commitment for lifelong learning which is important for their professional growth – substantiate the statement.
4 Marks

More from Biochemistry

Previous-year question paper.More papers →Report an issue