RGUHS MBBS Biochemistry March 2022 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2022 · March · CBME

Questions (30)

1.A 8 year old boy was brought to orthopaedic OPD with a complaint of abnormal gait for the past 3 months. Clinical examination showed tenderness over Tibia. Laboratory investigation data revealed a. Name the vitamin D deficiency disorder in the above case b. What is the RDA of vitamin D? c. Explain the formation of calcitriol d. Describe the role of calcitriol in calcium homeostasis
10 Marks
2.Explain glycogenolysis. Write the difference between Liver and Muscle glycogenolysis. Mention the role of insulin and glucagon in glycogenolysis.
10 Marks
3.A pregnant lady who visited primary health care centre for antenatal check-up with complaints of tiredness and easy fatigability was found to be anemic. Peripheral smear showed microcytic hypochromic anemia. a. Name the mineral associated with the above disorder b. Write the dietary sources and RDA of the above mineral c. Write the biochemical functions of above mineral.
5 Marks
4.A 60 year old obese man, who underwent master health check-up was found to have mild hepatomegaly with fatty liver changes. a. What is fatty liver? b. Enumerate the causes of fatty liver c. Explain the role of lipotropic factors in preventing fatty liver.
5 Marks
5.Mention blood buffers. Explain the role of Lungs in acid base balance.
5 Marks
6.List five functions of phosphorous.
5 Marks
7.Describe steps in Ketogenesis. Mention two conditions associated with Ketonuria.
5 Marks
8.What is chemiosmotic hypothesis? Explain how proton gradient is utilized for ATP synthesis.
5 Marks
9.Describe competitive inhibition of enzymes with two examples.
5 Marks
10.Define Basal Metabolic Rate (BMR). Mention four factors affecting BMR.
5 Marks
11.Mention three functions of cholesterol.
3 Marks
12.What is HbA1C (Glycated Hemoglobin)? Mention its significance.
3 Marks
13.What are therapeutic enzymes? Give two examples with their therapeutic application.
3 Marks
14.What is facilitated diffusion? Give one example.
3 Marks
15.What is the role of Anti Diuretic Hormone (ADH) in water balance? Name the disorder associated with its deficiency.
3 Marks
16.What is Alkali reserve? List two causes of metabolic acidosis.
3 Marks
17.What is Marasmus? List two features of Marasmus.
3 Marks
18.Define Km. What is the significance of Km?
3 Marks
19.Name three mucopolysaccharides and write their functions.
3 Marks
20.Troponins are more specific cardiac marker compared to creatine kinase – Justify.
3 Marks
21.Osteogenesis imperfecta is due to defect in: A. Actin B. Collagen C. Keratin D. Crystallin
1 Mark
22.Galactosyl transferase is marker for A. Cell membrane B. Mitochondria C. Lysosomes D. Golgi complex
1 Mark
23.Bile acid is derived from A. Cholesterol B. Glycerol C. Fatty acids D. Billirubin
1 Mark
24.Inulin is a polymer of A. Glucose B. Fructose C. Mannose D. Galactose
1 Mark
25.Which of the following mineral is best known for antioxidant role? A. Calcium B. Iron C. Phosphorus D. Selenium
1 Mark
26.Phospholipid deficiency in respiratory distress syndrome is A. Sphingomyelin B. Phosphatidyl ethanolamine C. Plasmalogen D. Lecithin
1 Mark
27.Hyponatremia is seen in A. Addison’s disease B. Cushing’s disease C. Primary hyperaldosteronism D. Steroid therapy
1 Mark
28.Administration of loop diuretics leads to A. Metabolic acidosis B. Metabolic alkalosis C. Respiratory acidosis D. Respiratory alkalosis
1 Mark
29.Positive nitrogen balance is seen in A. Pregnancy B. Malignancies C. Malnutrition D. Chronic illness
1 Mark
30.Enzymes synthesized in inactive form is called as A. Coenzymes B. Apoenzymes C. Proenzymes D. Lysozymes
1 Mark

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