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RGUHS MBBS Biochemistry February 2023 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2023 · February · CBME

Questions (30)

  1. 1.A medical student who had an exam on the next day did not eat anything the previous night. Next day morning, he had severe headache and giddiness before exam. His fasting plasma glucose was 48 mg/dl. a) Interpret the plasma glucose value b) Name the metabolic pathways which maintain blood glucose in fasting state c) Explain the metabolic pathway that synthesise glucose from pyruvate
    10 Marks
  2. 2.Mention the active form of Vitamin D. Describe the synthesis, biochemical functions and RDA of Vitamin D.
    10 Marks
  3. 3.A 48-year-old man diagnosed with myocardial infarction (MI) had an altered lipid profile with elevated total cholesterol and LDL cholesterol. a) Write the biological reference interval of LDL cholesterol. b) Explain the formation of LDL cholesterol. c) Reason out why LDL cholesterol is atherogenic.
    5 Marks
  4. 4.A 70-year-old man suffered an attack of pneumonia. He found it difficult to breathe and was losing consciousness. His Arterial Blood Gas (ABG) report was as follows: pH=7.1, pCO2 = 52 mmHg, Plasma Bicarbonate (HCO3-) = 25 meq/L. a) Interpret the ABG report. b) Write the compensatory mechanism in the above acid-base disorder.
    5 Marks
  5. 5.Mention biological reference interval for serum calcium. Describe any four functions of calcium.
    5 Marks
  6. 6.Define Isoenzymes. Mention the Isoenzymes of creatine phosphokinase (CPK) and write their significance.
    5 Marks
  7. 7.Define Basal Metabolic Rate (BMR). Enumerate the factors affecting BMR.
    5 Marks
  8. 8.Explain the metabolic adaptations in well-fed state.
    5 Marks
  9. 9.Explain competitive inhibition of enzymes with two examples.
    5 Marks
  10. 10.Explain the functions of peroxisomes and describe their role in fatty acid oxidation.
    5 Marks
  11. 11.What is fatty liver? Mention any two lipotropic factors.
    3 Marks
  12. 12.What is hyponatremia? List two causes of hyponatremia.
    3 Marks
  13. 13.Component of oral rehydration solution (ORS) has sodium chloride and glucose. What is purpose of adding glucose in ORS?
    3 Marks
  14. 14.Mention any three site specific inhibitors of electron transport chain.
    3 Marks
  15. 15.Name the enzyme defect in von Gierke’s disease. Write the biochemical alterations in von Gierke’s disease.
    3 Marks
  16. 16.What is the cause of pellagra? Write the clinical manifestations of pellagra.
    3 Marks
  17. 17.A diabetic patient was advised not to take polished rice but to take brown rice. Explain the reasons for the same.
    3 Marks
  18. 18.Mention three homopolysccharides of glucose and write their biological importance.
    3 Marks
  19. 19.Write the biochemical defect in Ehler Danlos Syndrome and Osteogenesis imperfecta.
    3 Marks
  20. 20.Write the biochemical cause of respiratory distress syndrome in premature babies.
    3 Marks
  21. 21.Hexokinase belongs to which class of enzymes? A. Oxidoreductase B. Transferase C. Hydrolase D. Lyase
    1 Mark
  22. 22.The sugar component of cerebroside is A. Galactose B. Lactose C. Fructose D. Ribose
    1 Mark
  23. 23.The normal Anion gap is A. 4-8 mmol/L B. 10-14 mmol/L C. 16-20 mmol/L D. 22-26 mmol/L
    1 Mark
  24. 24.Which of the following vitamins is used in the electron transport chain? A. Riboflavin B. Pantothenic acid C. Pyridoxine D. Biotin
    1 Mark
  25. 25.Glucose and fructose are monosaccharide units of A. Lactose B. Maltose C. Sucrose D. Isomaltose
    1 Mark
  26. 26.Limiting amino acid in the protein gelatin is A. Lysine B. Threonine C. Tryptophan D. Methionine
    1 Mark
  27. 27.In Wilson’s disease copper accumulates in all of the following tissues EXCEPT A. Eyes B. Spleen C. Brain D. Liver
    1 Mark
  28. 28.Hormone insulin activates which of the following pathway A. Glycogenolysis B. Gluconeogenesis C. Glycolysis D. Lipolysis
    1 Mark
  29. 29.The marker enzyme for microsomes is A. ATP synthase B. Cathepsin C. Glucose-6-phosphatase D. Lactate dehydrogenase
    1 Mark
  30. 30.Which coenzyme is responsible for carboxylation reactions A. Biocytin B. FAD C. NAD D. TPP
    1 Mark

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