RGUHS MBBS Biochemistry May 2023 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2023 · May · CBME

Questions (30)

1.A 10-year-old boy was admitted to a hospital with a diagnosis of malaria. He was started on primaquine and antipyretics. Within one day he was found to have developed hemolytic anemia. a) Name the pathway affected in the above case and write the enzyme defect in the pathway. b) Name the compounds formed in this pathway and write their importance. c) What is the relation between primaquine and hemolytic anemia?
10 Marks
2.Describe cholesterol biosynthesis up to the formation of mevalonate. Explain the regulation of cholesterol biosynthesis. Mention two causes of Hypercholesterolemia.
10 Marks
3.An 8-year-old girl presented with difficulty in vision during night time. Vitamin A deficiency was suspected following examination. a) Write the provitamin form of Vitamin A b) Explain Wald’s visual cycle
5 Marks
4.A 20-year-old pregnant woman presented with history of fatigue. Her peripheral blood smear showed microcytic hypochromic anemia. a) Which mineral deficiency leads to this type of anemia? b) Explain the absorption, transport and storage of this mineral.
5 Marks
5.Describe the role of dietary fibre in nutrition.
5 Marks
6.State chemiosmotic theory and illustrate the process of oxidative phosphorylation.
5 Marks
7.Define metabolic acidosis. Enumerate the causes for metabolic acidosis. Write the compensatory mechanism in metabolic acidosis.
5 Marks
8.Describe the role of any five plasma enzymes in the diagnosis of disease.
5 Marks
9.Explain niacin under the following headings: a) Dietary sources b) Co-enzyme forms c) Deficiency manifestation
5 Marks
10.Explain the metabolic changes in starvation.
5 Marks
11.Write the composition and functions of collagen.
3 Marks
12.Enumerate the biomarkers used in the diagnosis of myocardial infarction (MI). Which biomarker is considered specific for MI and why?
3 Marks
13.Name three functions of the vitamin whose deficiency causes scurvy.
3 Marks
14.Name three mucopolysaccharides and write their functions.
3 Marks
15.Name three phospholipids and write their biological importance.
3 Marks
16.Mention two causes of hypokalemia. Write biological reference interval for serum potassium.
3 Marks
17.Define Km. Explain its importance with an example.
3 Marks
18.Mention the role of carnitine in β-oxidation.
3 Marks
19.Write biological importance of selenium.
3 Marks
20.Define active transport. Give two examples for active transport.
3 Marks
21.The vitamin that acts as a coenzyme for transketolase activity is A. Pyridoxine B. Thiamine C. Biotin D. Folate
1 Mark
22.Enzymes which are synthesized in an inactive form are called A. Apoenzyme B. Proenzymes C. Coenzyme D. Isozyme
1 Mark
23.All the following lipids are present in the cell membranes EXCEPT A. Lecithin B. Cholesterol C. Sphingomyelin D. Triacylglycerol
1 Mark
24.The product of glycolysis in erythrocytes is A. Lactate B. Pyruvate C. Urate D. Acetate
1 Mark
25.Which of the following derivative of monosaccharide is used to reduce raised intra-cranial pressure? A. Sorbitol B. Dulcitol C. Ribitol D. Mannitol
1 Mark
26.Which of the following does not increase the absorption of calcium? A. Vitamin D B. Absence of bile salts C. Basic amino acids D. Acidity
1 Mark
27.Nitrogenous base ethanolamine is present in A. Phosphatidyl inositol B. Plasmalogen C. Cephalin D. Lecithin
1 Mark
28.Number of calories given by one gram of carbohydrate is A. 2 B. 4 C. 6 D. 9
1 Mark
29.Normal biological reference interval for serum sodium is A. 96-105 meq/L B. 116-135 meq/L C. 136-145 meq/L D. 156-165 meq/L
1 Mark
30.The ratio of bicarbonate to carbonic acid in bicarbonate buffer system is A. 20:1 B. 10:1 C. 4:1 D. 1:1
1 Mark

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