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RGUHS MBBS Biochemistry December 2024 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2024 · December · CBME

Questions (30)

  1. 1.A 12-year-old, with history of type 1 diabetes was brought to the emergency in a semi- comatose state with rapid breathing and fruity odour of breath. Investigations showed Random blood glucose of 450 mg/dL and positive test for the presence of ketone bodies. Arterial Blood Gas (ABG) analysis suggested features of metabolic acidosis. a) Write the reference interval for Fasting and Random plasma glucose. b) Mention the ketone bodies that answered the test in this case. c) Explain the synthesis and utilization of ketone bodies.
    10 Marks
  2. 2.Write the sources, coenzyme form, biochemical functions and deficiency manifestations of Thiamine.
    10 Marks
  3. 3.An elderly male visited orthopedic department with history of chronic pain in the knee joint. After examination, he was prescribed medication containing some of the heteropolysaccharides and advised to follow up after two months. a) What are heteropolysaccharides? b) Name the heteropolysaccharides that are present in cartilage and synovial fluid and mention their importance. c) Write the composition and biological importance of Heparin.
    5 Marks
  4. 4.A mother and 12 year her old son was brought with history of fever and headache. All investigations including Liver Function Test (LFT) were within normal limits for both and symptomatic treatment was advised. However, the mother was worried about higher Alkaline phosphatase (ALP) observed in the LFT of her son compared to her. The physician explained the physiological reason for the raised enzyme in the child. a) Mention the physiological reason for higher ALP in the above child. b) Name two pathological conditions for increase in serum ALP. c) Explain the role of isoenzymes in the diagnosis Myocardial infarction.
    5 Marks
  5. 5.Write two biological functions and a disorder associated with the metabolism of a) Iron b) Copper.
    5 Marks
  6. 6.Describe the electron transport chain.
    5 Marks
  7. 7.Name the carbohydrate shunt pathways in RBC. Explain their biological importance.
    5 Marks
  8. 8.Explain the regulation of blood glucose in starvation.
    5 Marks
  9. 9.What is the normal pH of blood? Name the buffer systems that maintain blood pH. What is the effect of pH on enzyme activity?
    5 Marks
  10. 10.Explain how calcium is regulated in the body. Mention its deficiency disorders.
    5 Marks
  11. 11.What are Dietary fibres? Why is it important to include them in the diet?
    3 Marks
  12. 12.Muscle glycogen does not contribute to blood glucose - Justify. Mention two glycogen storage disorders
    3 Marks
  13. 13.Name the essential fatty acids. Mention three biological importance poly unsaturated fatty acids
    3 Marks
  14. 14.What is glycated haemoglobin? Mention its diagnostic applications
    3 Marks
  15. 15.Write the function of the following lipases a) Lipoprotein lipase b) Hormone sensitive lipase c) Phospholipase A2
    3 Marks
  16. 16.Write two mechanisms of transport of large molecules across membrane. What is Hartnup’s disease?
    3 Marks
  17. 17.What is hyponatremia? Write two causes for the same.
    3 Marks
  18. 18.What is anion Gap? Write the reference range for normal anion gap.
    3 Marks
  19. 19.Write the features of competitive inhibition of enzymes.
    3 Marks
  20. 20.Write three differences between Marasmus and Kwashiorkar.
    3 Marks
  21. 21.The enzyme used in diagnosis of prostate cancer is A. Acid phosphatase B. Alkaline phosphatase C. Lactate dehydrogenase D. Alanine transaminase
    1 Mark
  22. 22.Which of the following is a glycoside? A. Digitonin B. Mannitol C. Glucuronic acid D. Glucosamine
    1 Mark
  23. 23.Transport of water through Aquaporins is an example of A. Simple diffusion B. Facilitated diffusion C. Primary active transport D. Secondary active transport
    1 Mark
  24. 24.Which of the following is a derivative of cholesterol A. Vitamin A B. Vitamin E C. Vitamin D D. Vitamin K
    1 Mark
  25. 25.The cholesterol lowering effect of statins is by inhibiting A. HMG CoA reductase B. HMG CoA lyase C. HMG CoA Synthase D. Cholesterol esterase
    1 Mark
  26. 26.Which of the following amino acid in collagen is hydroxylated A. Glycine B. Tyrosine C. Threonine D. Lysine
    1 Mark
  27. 27.Which of the following contains iron? A. Ceruloplasmin B. Myoglobin C. Albumin D. Collagen
    1 Mark
  28. 28.Anemia can be caused by the deficiency of all EXCEPT A. Pyridoxine B. Vitamin B12 C. Vitamin C D. Riboflavin
    1 Mark
  29. 29.The following organs can utilize ketone bodies during starvation EXCEPT A. Liver B. Brain C. Heart D. Skeletal muscle
    1 Mark
  30. 30.Which of the following is a feature of respiratory acidosis? A. Decrease in Bicarbonate B. Increase in pCO2 C. Decreased hydrogen ion concentration D. Increase in rate and depth of respiration
    1 Mark

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