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RGUHS MBBS Biochemistry February 2024 (1024 CBME)

1024Rajiv Gandhi University of Health Sciences · Biochemistry · 2024 · February · CBME

Questions (30)

  1. 1.A 40-year-old navy officer contacted his physician for development of spongy and bleeding gums. He also had loosening of teeth, pain in the joints and complained of poor wound healing. History revealed that he was in submarine tour for 40 days and was only on staple diet. (a) Name the vitamin deficiency associated with symptoms in the above case. (b) Name the disorder caused due to deficiency of above vitamin. (c) List two dietary sources of above vitamin. (d) Mention any four biochemical functions of above vitamin. (e) Explain the biochemical basis of spongy and bleeding gums.
    10 Marks
  2. 2.Explain the hormonal regulation of glucose homeostasis. Mention the biological reference interval of fasting and post-prandial plasma glucose levels. Substantiate the role of glycated hemoglobin (HbA1c) in monitoring blood glucose levels.
    10 Marks
  3. 3.A 50-year-old man was diagnosed with hemorrhoids and underwent operation in relation to it. He had several bleeding episodes in the past and was found to have microcytic hypochromic anaemia. (a) Which mineral deficiency is associated with anaemia in the above case? (b) Mention two good dietary sources of above mineral. (c) Explain the process of absorption, transport and storage of the above mineral.
    5 Marks
  4. 4.The following are the values obtained in an Arterial Blood Gas (ABG) analysis. figure (a) Name the acid-base disorder based on the findings in the above report. (b) Mention the possible causes for the above acid-base disorder. (c) Explain the compensatory mechanism in the above acid-base disorder.
    5 Marks
  5. 5.What are dietary fibres? Give four examples of dietary fibres. Mention four advantages of consuming dietary fibres.
    5 Marks
  6. 6.What is carnitine? Explain its role in transport of fatty acids for oxidation process.
    5 Marks
  7. 7.Compare and contrast between passive and active transport with two examples.
    5 Marks
  8. 8.Explain competitive inhibition with two examples.
    5 Marks
  9. 9.Explain the steps in the synthesis and breakdown of ketone bodies.
    5 Marks
  10. 10.Define isoenzymes. Name two enzymes and their isoenzyme forms with their significance.
    5 Marks
  11. 11.Write the amino acid composition of collagen. Mention two clinical disorders associated with defective collagen.
    3 Marks
  12. 12.Give three examples of glycosaminoglycans with their functions.
    3 Marks
  13. 13.What are phospholipids? Mention the biochemical importance of lecithin and cephalin.
    3 Marks
  14. 14.Write the components of Complex I of electron transport chain and mention one inhibitor of this complex.
    3 Marks
  15. 15.Compare and contrast between kwashiorkor and marasmus.
    3 Marks
  16. 16.Name serum electrolytes. Mention two causes associated with hypokalemia.
    3 Marks
  17. 17.Write the features of bicarbonate buffer system.
    3 Marks
  18. 18.Write three features to differentiate type I and type II diabetes mellitus.
    3 Marks
  19. 19.Mention the role of oxidized LDL in atherogenesis.
    3 Marks
  20. 20.Write the clinical features associated with skeletal and dental fluorosis.
    3 Marks
  21. 21.Which one of the following is rich in saturated fatty acid? A. Coconut oil B. Groundnut oil C. Corn oil D. Sesame oil
    1 Mark
  22. 22.Which one of the following enzymes is specific to gluconeogenesis? A. Phosphohexose isomerase B. Pyruvate carboxylase C. Aldolase D. Enolase
    1 Mark
  23. 23.Optimum pH for alkaline phosphatase activity is A. 2-3 B. 4-5 C. 6-7 D. 9-10
    1 Mark
  24. 24.Which one of the following lipids is stored in adipose tissue? A. Triglyceride B. Phospholipid C. Cholesterol ester D. Free fatty acids
    1 Mark
  25. 25.Which of the following is an epimer of glucose? A. Galactose B. Ribose C. Erythrose D. Glyceraldehyde
    1 Mark
  26. 26.The rate limiting enzyme in denovo cholesterol synthesis is A. Acetoacetyl-CoA synthase B. HMG CoA synthase C. HMG CoA reductase D. Mevalonate kinase QP CODE : 1024
    1 Mark
  27. 27.Specific dynamic action for protein is A. 5 B. 13 C. 18 D. 30
    1 Mark
  28. 28.Which one of the following is an important urinary buffer? A. Bicarbonate B. Ammonia C. Phosphate D. Proteins
    1 Mark
  29. 29.Which one of the following is a good source of vitamin E? A. Cod liver oil B. Wheat germ oil C. Green leafy vegetables D. Egg yolk
    1 Mark
  30. 30.The condition Acrodermatitis enteropathica is due to deficiency of A. Selenium B. Iodine C. Zinc D. Manganese
    1 Mark

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