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RGUHS MBBS Biochemistry November 2023 (1025 CBME)

1025Rajiv Gandhi University of Health Sciences · Biochemistry · 2023 · November · CBME

Questions (30)

  1. 1.A 45 year old male presented with excruciating pain in the great toe. He was obese and had long history of consumption of alcohol. On investigation his serum uric acid level was 12.1 mg/dl a) Interpret the serum uric acid level in the above case b) Explain the formation of uric acid c) Write four causes of hyperuricemia d) Explain the biochemical basis of giving allopurinol in treatment of Gout
    10 Marks
  2. 2.Explain the process of DNA replication in prokaryotes. Mention two inhibitors of DNA replication. List two differences between prokaryotic and eukaryotic replication.
    10 Marks
  3. 3.a) A 3 year old child was brought to paediatric OPD with complaints of fair skin, white hair and ocular manifestations suggesting the case to be albinism a) What is the enzyme defect in albinism? b) Write the pathway of synthesis of melanin c) List two other biologically important compounds formed from tyrosine
    5 Marks
  4. 4.A 15 year old girl with history of vaso-occlusive pain crisis came to OPD with history of influenza attack. She was taking monthly blood transfusion from the age of 5 years due to underlying sickle cell disease. a) Explain the molecular defect in sickle cell disease and biochemical basis of sickling b) Mention the laboratory investigations in sickle cell disease
    5 Marks
  5. 5.b) Define clearance. Explain creatinine clearance test. Give reason why creatinine clearance is preferred over urea clearance
    5 Marks
  6. 6.List the immunoglobulins. Write the functions of these immunoglobulins
    5 Marks
  7. 7.Explain the steps in recombinant DNA technology
    5 Marks
  8. 8.Name the antioxidant enzymes and explain their mechanism of action
    5 Marks
  9. 9.List five plasma proteins and mention their functions
    5 Marks
  10. 10.Explain primary and secondary structural organisation of proteins with examples
    5 Marks
  11. 11.What is gene therapy? Name two diseases in which gene therapy is used
    3 Marks
  12. 12.Name three preanalytical errors in a clinical laboratory
    3 Marks
  13. 13.Mention different types of RNA and write their functions
    3 Marks
  14. 14.What is the defective enzyme in homocystinuria? What are the characteristic features of homocystinuria?
    3 Marks
  15. 15.Mention the types of mutation. Give reason why some mutations are silent
    3 Marks
  16. 16.What is Restriction Fragment Length Polymorphism (RFLP)? Give the clinical applications of RFLP
    3 Marks
  17. 17.Enumerate the specialized products derived from Tryptophan. Mention their biological functions
    3 Marks
  18. 18.What are oncosupressor genes? Mention their clinical significance with two examples
    3 Marks
  19. 19.Explain with three examples the process of detoxification by conjugation mechanism
    3 Marks
  20. 20.Enumerate the tests to assess thyroid function. Write the laboratory findings in case of hyperthyroidism
    3 Marks
  21. 21.The enzyme defective in porphyria cutanea tarda is A. PBG deaminase B. Uroporphyrinogen decarboxylase C. Heme synthase D. Coproporphyrinogen III oxidase
    1 Mark
  22. 22.Tumor marker elevated in liver cancer is A. Alpha feto protein B. Prostate specific antigen C. Ca 125 D.  – HCG
    1 Mark
  23. 23.Which of the following is a semi essential amino acid? A. Arginine B. Alanine C. Aspartic acid D. Glycine
    1 Mark
  24. 24.Which of the following is an exopeptidase? A. Trypsin B. Chymotrypsin C. Pepsin D. Carboxypeptidase
    1 Mark
  25. 25.Nitrogenous base present both in DNA and RNA is A. Uracil B. Thymine C. Cytosine D. Xanthosine
    1 Mark
  26. 26.Reference interval for microalbumin in urine is A. 830-1100 mg / day B. 630-800 mg/ day C. 430-600 mg / day D. 30-300 mg /day
    1 Mark
  27. 27.Urinary urobilinogen is increase in A. Hemolytic jaundice B. Hepatic jaundice C. Obstructive jaundice D. Physiological jaundice
    1 Mark
  28. 28.Northern blotting technique is used for identification of A. RNA B. DNA C. Protein D. Lipoprotein
    1 Mark
  29. 29.Cancer cells are immortal due to the activity of A. Ligase B. Helicase C. Telomerase D. Topoisomerase
    1 Mark
  30. 30.Biological reference interval of serum creatinine in males is A. 0.1 to 0.5 mg/dl B. 0.8 to 1.2 mg/dl C. 1.5 to 2.2 mg/dl D. 2.4 to 3.1 mg/dl
    1 Mark

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