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RGUHS MBBS Biochemistry February 2024 (1025 CBME)

1025Rajiv Gandhi University of Health Sciences · Biochemistry · 2024 · February · CBME

Questions (30)

  1. 1.A fair 5 year old child was brought to the hospital by his parents, who complained of delayed milestones in the child. Investigations revealed a high phenylalanine content in the blood and a diagnosis of phenylketonuria was made. a) Name the enzyme defect in the above disorder. b) Explain the pathway for catabolism of phenylalanine. c) Name the compound responsible for the mousy odour in the above condition. d) List the biochemical investigations in phenylketonuria
    10 Marks
  2. 2.Explain the process of recombinant DNA technology and list four applications in the field of medicine.
    10 Marks
  3. 3.A 40 year old female with history of gall stones presented with acute pain abdomen, yellowish discoloration of sclera and passing clay coloured stools. Following investigations, a diagnosis of obstructive jaundice was made. a) Describe van Den Berg test and its findings in this condition. b) Name the enzyme that is elevated in this condition. c) Explain the biochemical reason for clay coloured stools in this case.
    5 Marks
  4. 4.A 50 year old female presented with hoarseness of voice, dryness of skin and excess weight gain. The case was suspected to be hypothyroidism. a) List the tests for assessment of thyroid function. b) Write laboratory findings in a case of hypothyroidism. c) Differentiate between primary and secondary hypothyroidism.
    5 Marks
  5. 5.Define proto-oncogene and oncogene. Explain the activation of oncogene.
    5 Marks
  6. 6.Compare and contrast between replication in prokaryotes and eukaryotes.
    5 Marks
  7. 7.Enumerate kidney function tests. Explain tubular function test.
    5 Marks
  8. 8.Describe DNA repair mechanism with suitable examples.
    5 Marks
  9. 9.What is gout? Write the causes and clinical features of gout.
    5 Marks
  10. 10.Enumerate the functional classification of proteins with examples.
    5 Marks
  11. 11.Draw and label the cell cycle.
    3 Marks
  12. 12.What are histones? Enumerate their functions.
    3 Marks
  13. 13.Draw a neat labelled diagram of immunoglobulin.
    3 Marks
  14. 14.What are restriction endonucleases? Mention their importance.
    3 Marks
  15. 15.Give biological reference interval of serum urea, serum albumin and serum creatinine.
    3 Marks
  16. 16.Enumerate post-transcriptional modifications and write their significance.
    3 Marks
  17. 17.Mention any three antioxidants and state their mechanism of action.
    3 Marks
  18. 18.Write the structure and function of t-RNA
    3 Marks
  19. 19.Give three examples for detoxification by conjugation mechanism.
    3 Marks
  20. 20.Name thee pre-analytical variables that affect the biochemical laboratory results.
    3 Marks
  21. 21.Hypoalbuminemia is seen in all the following conditions EXCEPT A. Cirrhosis of liver B. Nephrotic syndrome C. Kwashiorkor D. Dehydration
    1 Mark
  22. 22.Bile salts and bile pigments are excreted in urine in A. Incompatible blood transfusion B. Gilbert’s syndrome C. Carcinoma of head of pancreas D. Crigler-Najjar syndrome
    1 Mark
  23. 23.Which of the following is a secretory immunoglobulin? A. IgG B. IgA C. IgM D. IgD
    1 Mark
  24. 24.Which of the following is an essential amino acid? A. Glycine B. Phenyl alanine C. Aspartic acid D. Serine
    1 Mark
  25. 25.Deficiency enzyme causing alkaptonuria is A. Tyrosinase B. Fumarylacetoacetate hydrolase C. Homogentisate oxidase D. Dopa decarboxylase
    1 Mark
  26. 26.-1 antitrypsin deficiency is associated with A. Wilson’s disease B. Cirrhosis of liver C. Emphysema D. Multiple myeloma
    1 Mark
  27. 27.Which of the following is an example of enzyme which scavenges free radicals? A. Hexokinase B. Aconitase C. Fumarase D. Catalase
    1 Mark
  28. 28.CA 125 is a tumor marker for A. Ovarian cancer B. Hepatoma C. Carcinoma breast D. Pheochrmocytoma
    1 Mark
  29. 29.Which of the following conditions is not associated with hyperuricemia? A. Gout B. Leukemia C. Psoriasis D. Xanthinuria
    1 Mark
  30. 30.Clearance values of all of the following compounds are used to test glomerular function of kidney EXCEPT A. Glucose B. Creatinine C. Inulin D. Urea
    1 Mark

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