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RGUHS MBBS Biochemistry October 2025 (5505 CBME)

5505Rajiv Gandhi University of Health Sciences · Biochemistry · 2025 · October · CBME

Questions (27)

  1. 1.What are the components of a lipid profile? Mention their normal reference range. Describe the metabolism of Lipoproteins in detail
    10 Marks
  2. 2.a) Acidosis is associated with hyperkalemia. Give reason b) Alkalosis is associated with hypokalemia. Give reason
    3 Marks
  3. 3.a) G6PD protects against malaria, justify b) Alcoholics are prone to Hypoglycemia, justify
    3 Marks
  4. 4.a) Iron is one-way element substantiate. b) Wilson's disease is associated with bronze diabetes, substantiate
    3 Marks
  5. 5.a) Benedict's test is semiquantitative. Justify b) Cellulose is not digested by humans. Give reasons
    3 Marks
  6. 6.a) Vitamin B12 deficiency results in a Folate trap. Why? b) Vitamin K injection is given to all newborns. Why?
    3 Marks
  7. 7.Describe the regulation of blood glucose. Mention the normal level of haemoglobin A1c in healthy individuals, pre-diabetics and Diabetics. Write its significance
    5 Marks
  8. 8.A 6-year-old boy presents with spongy bleeding gums, swollen gingiva, and painful swelling of joints with pale conjunctivae. The pediatrician advised the mother to give plenty of citrus fruits to her child a) What is the probable diagnosis? b) Which biomolecule is deficient in this condition? c) What are the functions of this biomolecule?
    5 Marks
  9. 9.A 48-year-old man suddenly develops excruciating pain and is rushed to the hospital. ECG reveals massive myocardial infarction. a) List all cardiac enzymes used for the diagnosis of myocardial infarction and their pattern of elevation. b) Which is the most specific biomarker for Myocardial Infarction? c) Which is the most commonly used thrombolytic agent for myocardial infarction?
    5 Marks
  10. 10.Describe the composition, functions, and applied aspects of phospholipids
    5 Marks
  11. 11.Describe the Chemiosmotic theory of Oxidative phosphorylation. Add a note on its inhibitors
    5 Marks
  12. 12.Describe any five different transport mechanisms with examples.
    5 Marks
  13. 13.Classify enzyme inhibition. Describe competitive enzyme inhibition with suitable examples
    5 Marks
  14. 14.Define an Anion gap. Mention its normal reference range. Describe different types of anion gap with examples
    5 Marks
  15. 15.What are dietary fibers? Give examples. Mention their RDA. List their functions
    5 Marks
  16. 16.Mention the normal reference interval for serum calcium. What is the RDA for calcium? Describe the regulation of blood calcium
    5 Marks
  17. 17.Enumerate and describe the professional qualities of the roles of a Physician
    5 Marks
  18. 18.Laboratory investigation of a 52-year-old man reveals his random blood glucose 100 mg/dl and urine glucose 1.5%
    (i) What could be the cause of the above lab report? A. Diabetes mellitus B. Fructosuria C. Pentosuria D. Renal glycosuria
    (ii) Renal threshold for glucose is A. 180 mg/dl B. 170 mg/dl C. 160 mg/dl D. 150 mg/dl
    2 Marks
  19. 19.A 12-year-old child presents to a Pediatrician with complaints of thick mucus secretions, repeated lung infections, fatty stools, and decreased weight for his age. The pediatrician suspects cystic fibrosis.
    (i) Choose an appropriate laboratory test that is impaired in Cystic Fibrosis A. Increased chloride in sweat B. Decreased chloride in sweat C. Increased chloride in blood D. Decreased chloride in blood
    (ii) Cystic fibrosis occurs as a result of a mutation in the following ABC family of transporter gene A. MRP 2 B. ABC B 4 C. ATP 7B D. CFTR
    2 Marks
  20. 20.Diagnosis of congestive cardiac failure was made in a 65-year-old man. He was prescribed digoxin.
    (i) Identify the nature of this drug A. Amino sugar B. Glycoside C. Glycoprotein D. Glycolipid
    (ii) Digoxin is formed by condensation of alcohol with the OH group of this carbohydrate A. Glucose B. Galactose C. Fructose D. Mannose
    2 Marks
  21. 21.A 10-year-old child presents to a Pediatrician with yellowish discoloration of teeth. The pediatrician suspects fluorosis.
    (i) Dental fluorosis results when the concentration of fluoride in water is more than A. 5 PPM B. 10 PPM C. 15 PPM D. 20 PPM
    (ii) The Pediatrician asks the parents to check the fluoride level in the water. What is the safe limit of fluoride in water to prevent fluorosis? A. Less than 1 PPM B. Less than 5 PPM C. Less than 2 PPM D. Less than 3 PPM
    2 Marks
  22. 22.A 52-year-old known diabetic gets his electrolytes checked in a lab.
    (i) Identify the electrolyte imbalance due to hyperglycemia A. Dilutional hypernatremia B. Dilutional hyponatremia C. Dilutional hypokalemia D. Dilutional hyperkalemia
    (ii) What is the probable disturbance in fluid volume in this patient? A. Hypertonic expansion B. Hypotonic expansion C. Hypertonic contraction D. Hypotonic contraction
    2 Marks
  23. 23.A man doing a moderate amount of work and weighing 55kg approaches you to know his daily energy requirement.
    (i) Choose the correct calorie requirement A. 2050kcal/day B. 3050kcal/day C. 1050kcal/day D. 550kcal/day
    (ii) What is the percentage of extra calories that has to be considered towards SDA if the person is consuming mixed diet A. 5% B. 10% C. 15% D. 20%
    2 Marks
  24. 24.A chronic alcoholic is brought to the hospital with impaired speech.
    (i) What could be the amount of alcohol consumed by this person? A. <50 ml B. 50-150 ml C. 150-300ml D. 300-400ml
    (ii) Alcohol is metabolized by all of the following enzymes EXCEPT A. Alcohol reductase B. Alcohol dehydrogenase C. Aldehyde dehydrogenase D. Microsomal ethanol oxidizing system
    2 Marks
  25. 25.A 22-year-old female is diagnosed with Pulmonary Tuberculosis and is prescribed anti- tubercular treatment, and INH is one of its components.
    (i) Identify the drug-induced vitamin deficiency A. Folic acid deficiency B. Vitamin B 12 deficiency C. Pyridoxine deficiency D. Niacin deficiency
    (ii) Which is the active form of this vitamin? A. TPP B. FAD C. NAD D. PLP
    2 Marks
  26. 26.A 10-year-old boy is diagnosed with Osteogenesis imperfecta.
    (i) Identify the biochemical defect in this condition where glycine in collagen is replaced by A. Glycine B. Cysteine C. Lysine D. Proline
    (ii) Collagen has this characteristic structure. Choose the appropriate one: A. Triple helical B. Quarter staggered C. Triple helical & quarter staggered D. Helical & quarter staggered
    2 Marks
  27. 27.Autopsy of a 2-year-old child reveals accumulation of glycogen in lysosomes of hepatocytes, heart and muscle
    (i) Identify the inborn error of metabolism A. Von Gierke’s disease B. Pompe’s disease C. Her’s disease D. McArdle’s disease
    (ii) Deficiency of which enzyme results in the disorder mentioned above A. Glucose 6 phosphatase B. Branching enzyme C. Debranching enzyme D. Lysosomal maltase
    2 Marks

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