KUHS MBBS Physiology Previous Question Paper - August 2025 (114001 2019 and 2024 Scheme)

114001Kerala University of Health Sciences · Physiology · 2025 · August · 2019 and 2024 Scheme

Questions (18)

1.A middle aged male with a hyperfunctioning thyroid nodule underwent a complete thyroidectomy. Postoperatively, he complained of circumoral numbness and tingling. Examination showed a normal pulse rate, body temperature, and blood pressure. Applying pressure to the cuff caused muscular spasm below it. The consultant instructed the duty doctor to tap the face just below the zygomatic bone and order lab tests for serum calcium, phosphate, and PTH levels
What clinical sign is being tested when the duty doctor taps the face just below the zygomatic bone a) Trousseau’s sign c) Babinski’s sign b) Chvostek’s sign d) Kernig’s sign
Which of the following is the most likely laboratory finding in this patient post-thyroidectomy a) High serum calcium and phosphate c) High serum calcium and low phosphate b) Low serum calcium and phosphate d) Low serum calcium and high phosphate
The probable cause of case would be a) Deficiency of Calcitonin c) Deficiency of PTH b) Deficiency of Thyroxin d) Deficiency of Iodine
An increase in serum calcium level above the normal triggers the release of a) Paratharmone (PTH) b) Calcitriol c) Calcitonin d) Thyroxin
The primary action of Calcitriol (1,25-dihydroxycholecalciferol) is a) Decrease calcium absorption in the intestines c) Decrease calcium reabsorption in the kidneys b) Increase calcium absorption in the intestines d) Increase phosphate excretion in the kidneys
5 Marks
2.Two statements marked as - Assertion (A) and Reason (R). Mark your answer as per the options provided a) A is correct R is incorrect c) Both A & R are correct and R is the reason for A b) A is incorrect R is correct d) Both A & R are correct and R is not reason for A
Assertion: In Acromegaly Bitemporal hemianopia may occur. Reason: Pituitary adenoma compresses optic chiasm.
Assertion: The duration of spinal shock is more in humans than frogs and cats. Reason: The duration of spinal shock is proportionate to the degree of encephalization of motor functions in various species
Assertion: In myopia, the distant objects appear blurred or unclear. Reason: Image is formed behind the retina.
Assertion: In skeletal muscle the twitch duration is shorter in fast muscle fibres in comparison with slow muscle fibres. Reason: On the basis of duration of their twitch contraction, motor units are divided into slow and fast units.
Assertion: Synaptic transmission in chemical synapse is unidirectional. Reason: The presynaptic terminal releases neurotransmitters, which bind to specific receptors located only on the postsynaptic membrane
5 Marks
3.Multiple response type questions. Read the statements and mark the answers appropriately.
The hormones secreted by adrenal cortex are: 1) Cortisol 2) Aldosterone 3) Adrenaline 4) Dehydroepiandrosterone a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 1, 2 and 4 are correct d) 2, 3 and 4 are correct
The following are features of cerebellar disorder. 1) Dysarthria 2) Dysmetria 3) Dysphagia 4) Dysdiadochokinesia a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 1, 2 and 4 are correct d) 2, 3 and 4 are correct
The body fluid compartments measurable by Dye dilution method are: 1) Plasma 2) Intracellular fluid 3) Extracellular fluid 4) Total body water a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 1, 2 and 4 are correct d) 2, 3 and 4 are correct
The primary colours as per Young – Helmholtz theory of colour vision are 1) Blue 2) Green 3) Yellow 4) Red a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 1, 2 and 4 are correct d) 2, 3 and 4 are correct
The basic taste modalities are: 1) Sweet 2) Sour 3) Salt 4) Spicy a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 1, 2 and 4 are correct d) 2, 3 and 4 are correct
5 Marks
4.Single response type questions
D (delta) cells of pancreas secrete a) Insulin b) Glucagon c) Somatostatin d) Pancreatic polypeptide
Sarcomere referes to the portion of myofibril between: a) A and H band b) Z line and A band c) Two adjacent Z lines d) A and I band
Anterograde amnesia is typically associated with damage to the: a) Amygdala b) Hippocampus c) Cerebellum d) Thalamus
The mossy fibers in cerebellum make direct synaptic connections with: a) Granule cells b) Purkinje cells c) Stellate cells d) Basket cells
The first sign of puberty in females is: a) Thelarche b) Menarche c) Pubarche d) Adrenarche
5 Marks
5.A 35-year-old female presents with weight gain, especially around her abdomen and face, fragile skin, easy bruising, acne, fatigue, mood swings, and irregular periods over the past 6 months. She also reports increased thirst and frequent urination. Examination reveals high blood pressure, a moon-shaped face, buffalo hump, purple striae, and thin, easily bruised skin. a) Name the most probable clinical condition and mention its cause. b) Describe the physiological action of cortisol. c) Explain the physiological basis of clinical features observed in the above case.
10 Marks
6.Describe the origin, course, and termination of pain pathway from left lower limb. Add a note on referred pain.
10 Marks
7.Describe the abnormalities of growth hormone secretion.
6 Marks
8.Describe the connections and functions of Basal ganglia.
6 Marks
9.Explain the pupillary light reflexes. Add a note on Argyll Robertson Pupil.
6 Marks
10.Explain the role of hypothalamus in the regulation of water and food intake
6 Marks
11.List the hormones secreted by placenta. Add a note on fetoplacental unit
6 Marks
12.Describe how impulse travels across the neuromuscular junction. Add a note on neuromuscular blockers.
6 Marks
13.Draw and label sodium – potassium ATPase
4 Marks
14.Give the physiological basis of impedance matching.
4 Marks
15.Physiological basis of oral contraceptive pills.
4 Marks
16.Draw and label the pathway of stretch reflex
4 Marks
17.Physiological basis of polyuria and polydypsia in diabetes mellitus
4 Marks
18.Draw and label taste pathway
4 Marks

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