KUHS MBBS Physiology Previous Question Paper - November 2025 (114001 2019 and 2024 Scheme)

114001Kerala University of Health Sciences · Physiology · 2025 · November · 2019 and 2024 Scheme

Questions (18)

1.58-year-old female complains of progressive weight gain of 5 kg in one year, fatigue, slight memory loss, slow speech, dry skin, constipation and cold intolerance. On examination body temperature 96.80 F, pulse is 58/min, BP 140/100mmH g. She is moderately obese and has puffy face with dry thick skin. The thyroid gland is slightly enlarged.
Clinical features not seen in hyperthyroidism a) Bradycardia b) Increased systolic B.P c) Tremor d) Warm skin
Thyroid hormone is derived from a) Thiamine b) Tryptophan c) Tyrosine d) Threonine
Thyroid hormone mainly effective at tissue level is a) Free T3 b) Free T4 c) MIT d) DIT
Thyroid hormone binds to which receptor a) Membrane b) Nuclear c) Cytoplasmic d) Mitochondria
Calcitonin is secreted by a) Parathyroid b) Kidney c) Thymus d) Thyroid
5 Marks
2.Two statements marked as - Assertion (A) and Reason (R). Mark your answer as per the options provided a) Both A & R are correct and R is the reason for A c) A is correct R is incorrect b) Both A & R are correct but R is not reason for A d) A is incorrect R is correct
Assertion: Sarcotubular system is made up of a T system and a sarcoplasmic reticulum Reason: Tropomyosin inhibits the interaction of myosin with actin
Assertion: Hypokinetic features of Parkinson’s disease are rigidity and tremor Reason: Parkinson’s disease is due to degeneration of nigrostriatal dopaminergic fibers
Assertion: Protrusion of lower jaw is seen in acromegaly Reason: Hyper secretion of growth hormone in adults
Assertion: Bone conduction is better than air conduction in middle ear infections Reason: Tympanic reflex is the function of middle ear
Assertion: Ataxia and dysmetria are the clinical features seen in cerebellar disease Reason: Cerebellum is concerned with adjustments that make coordination easier
5 Marks
3.Multiple response type questions. Read the statements and mark the answers appropriately
Sensations carried by the spinothalamic tract are 1) Crude touch 2) Pain 3) Vibration 4) Temperature a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct d) 1, 2 and 4 are correct
Hyperglycemic hormones are 1) Insulin 2) Glucocorticoids 3) Glucagon 4) Growth hormone a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 2, 3 and 4 are correct d) 1, 2 and 4 are correct
Hormones contributing for the postnatal somatic growth are 1) Thyroid hormone 2) Growth hormone 3) Catecholamines 4) Androgens a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 2, 3 and 4 are correct d) 1, 2 and 4 are correct
Cell adhesion molecules are 1) Myosin 2) Integrins 3) Cadherin 4) Selectin a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 2, 3 and 4 are correct d) 1, 2 and 4 are correct
Higher mental functions are 1) Languague 2) Coordination 3) Learning 4) Memory a) 1, 2 and 3 are correct c) 1, 3 and 4 are correct b) 2, 3 and 4 are correct d) 1, 2 and 4 are correct
5 Marks
4.Single response type questions
Sperms acquire motility in a) Testis b) Vas deferens c) Epididymis d) Seminal vesicle
FSH is produced by a) Corticotropes b) Somatotropes c) Gonadotropes d) Lactotropes
Delta cells of pancreas produce a) Insulin b) Somatostatin c) Glucagon d) Pancreatin
Gamma motor neurons are mainly influenced by a) Reticulospinal tract b) Tectospinal tract c) Corticospinal tract d) Vestibulospinal tract
Rough endoplasmic reticulum is the site of synthesis of a) Cholesterol b) Carbohydrate c) Protein d) Mucopolysaccharides
5 Marks
5.A 45-year-old female patient was presented with palpitations, loss of weight in spite of good appetite and intolerance to heat. On examination she had fine tremors, thyroid nodule and mild exophthalmos. Blood report showed decreased TSH and elevated T3, T4 levels a) Name the most probable clinical condition (1) b) Describe the actions of the affected hormone (5) c) Physiological basis for palpitation and exophthalmos in this patient
10 Marks
6.Trace the pain pathway from (R) lower limb. Describe the analgesia system of the body
10 Marks
7.Role of hypothalamus in feeding and satiety. Physiological basis for polyphagia in Diabetes Mellitus
6 Marks
8.Draw and label the auditory pathway. Describe impedance matching
6 Marks
9.Describe the excitation- contraction coupling in skeletal muscles
6 Marks
10.Describe the neuroendocrine reflex and physiological basis for onset of puberty
6 Marks
11.Describe the actions and regulation of anti- diuretic hormone
6 Marks
12.Describe the actions of estrogen in various tissues
6 Marks
13.Differentiate between REM and NREM sleep. Add a note on narcolepsy
4 Marks
14.Physiological basis for phantom limb
4 Marks
15.Draw and label a muscle spindle and list its functions
4 Marks
16.Physiological basis for rigidity in UMN lesions
4 Marks
17.Describe the qualities of a good doctor patient relationship.
4 Marks
18.Functions of Serotoli cells
4 Marks

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